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Details on Person Lipo-K259-DLAT [mitochondrial matrix]

Class:Id	EntityWithAccessionedSequence:69969
_displayName	Lipo-K259-DLAT [mitochondrial matrix]
_timestamp	2024-02-21 17:03:05
compartment	[Compartment:5460] mitochondrial matrix
endCoordinate	647
hasModifiedResidue	[ModifiedResidue:1169151] N6-lipoyl-L-lysine at 259
modified	[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:1169152] D'Eustachio, P, 2011-01-12 [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:6792676] Jassal, Bijay, 2015-08-25 [InstanceEdit:9858750] Stephan, Ralf, 2024-01-14 [InstanceEdit:9861969] Stephan, Ralf, 2024-02-21
name	Lipo-K259-DLAT pyruvate dehydrogenase E2 subunit Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex ODP2_HUMAN Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor E2 PDC-E2 70 kDa mitochondrial autoantigen of primary biliary cirrhosis PBC M2 antigen complex 70 kDa subunit
referenceEntity	[ReferenceGeneProduct:60872] UniProt:P10515 DLAT [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:369850] R-HSA-69969.3
startCoordinate	87
(activeUnit)	[CatalystActivity:9861662] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]
(hasComponent)	[Complex:69971] lipo-K132,K259-DLAT trimer [mitochondrial matrix] [Homo sapiens] [Complex:70077] pyruvate dehydrogenase E2 holoenzyme, S-acetyldihydrolipoamide linked [mitochondrial matrix] [Homo sapiens] [Complex:70081] pyruvate dehydrogenase E2 holoenzyme, dihydrolipoamide linked [mitochondrial matrix] [Homo sapiens]
(input)	[Reaction:9861626] SIRT4 cleaves lipoyl from DLAT [Homo sapiens] [Reaction:9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Homo sapiens]
(output)	[Reaction:9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT [Homo sapiens] [Reaction:9861616] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens]
(replacementInstances)	[_Deleted:1169153] Deletion of instance: 69970
(updatedInstance)	[_UpdateTracker:9870023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v36:[addHasModifiedResidue, modifyName] [_UpdateTracker:9878584] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v44:[modifyEndCoordinate, modifyStartCoordinate] [_UpdateTracker:9884442] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v45:[addName] [_UpdateTracker:9893023] Update Tracker - [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] - v54:[modifyName]
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No pathways have been reviewed or authored by Lipo-K259-DLAT [mitochondrial matrix] (69969)