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Details on Person UniProt:Q13112 CHAF1B
| Class:Id | ReferenceGeneProduct:69915 |
|---|---|
| _chainChangeLog | chain:1-559 added on Fri February 6 2015 |
| _displayName | UniProt:Q13112 CHAF1B |
| _timestamp | 2025-02-21 19:04:58 |
| chain | chain:1-559 |
| checksum | AD1846CC81B8DC9F |
| comment | FUNCTION Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.SUBUNIT Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. In G2 and S phase also monomeric CHAF1B is detected. Interacts with histones H3.1, H3.2 and H3.1t (PubMed:33857403).INTERACTION DNA replication foci. Cytoplasmic in M phase.DEVELOPMENTAL STAGE Active complex is found in G1, S and G2 phases.PTM Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is hyperphosphorylated and displaced into the cytosol. Progressivly dephosphorylated from G1 to S and G2 phase. Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases.SIMILARITY Belongs to the WD repeat HIR1 family. |
| description | recommendedName: fullName evidence="8"Chromatin assembly factor 1 subunit B shortName: CAF-1 subunit B alternativeName: Chromatin assembly factor I p60 subunit shortName: CAF-I 60 kDa subunit shortName: CAF-I p60 alternativeName: M-phase phosphoprotein 7 |
| geneName | CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 |
| identifier | Q13112 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell cycle Chaperone Chromatin regulator Cytoplasm Direct protein sequencing DNA damage DNA repair DNA replication Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CHAF1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962525] ENSEMBL:ENSG00000159259 CHAF1B [Homo sapiens] |
| secondaryIdentifier | CAF1B_HUMAN Q99548 |
| sequenceLength | 559 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:212095] CHAF1B [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13112 CHAF1B (69915)
