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Details on Person UniProt:O75694 NUP155

Class:Id	ReferenceGeneProduct:69914
_chainChangeLog	chain:1-1391 added on Sat February 7 2015;chain:1-1391 removed on Tue November 3 2015;initiator methionine:1 added on Tue November 3 2015;chain:2-1391 added on Tue November 3 2015;initiator methionine:1 for 69914 removed on Fri Nov 03 2023;initiator methionine: for 69914 added on Fri Nov 03 2023;initiator methionine: for 69914 removed on Fri Aug 15 2025;initiator methionine:1 for 69914 added on Fri Aug 15 2025
_displayName	UniProt:O75694 NUP155
_timestamp	2025-08-15 21:55:03
chain	initiator methionine:1 chain:2-1391
checksum	7F07A103AFF7EE1D
comment	FUNCTION Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.SUBUNIT Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUP42 in vitro. Forms a complex with NUP35, NUP93, NUP205 and lamin B.INTERACTION In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.ALTERNATIVE PRODUCTS Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.PTM Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).PTM Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the non-repetitive/WGA-negative nucleoporin family.SEQUENCE CAUTION Extended N-terminus.
description	recommendedName: Nuclear pore complex protein Nup155 alternativeName: 155 kDa nucleoporin alternativeName: Nucleoporin Nup155
geneName	NUP155 KIAA0791
identifier	O75694
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Atrial fibrillation Disease variant Disulfide bond Glycoprotein Isopeptide bond Membrane mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	NUP155
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8992007] ENSEMBL:ENSG00000113569 NUP155 [Homo sapiens]
secondaryIdentifier	NU155_HUMAN Q9UBE9 Q9UFL5
sequenceLength	1391
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:240667] UniProt:O75694-2 NUP155 [Homo sapiens] [ReferenceIsoform:401888] UniProt:O75694-1 NUP155 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:157690] NUP155 [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:9634170] NUP155 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O75694 NUP155 (69914)