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Details on Person UniProt:Q02241 KIF23
| Class:Id | ReferenceGeneProduct:69908 |
|---|---|
| _chainChangeLog | chain:1-960 added on Sat February 7 2015 |
| _displayName | UniProt:Q02241 KIF23 |
| _timestamp | 2024-11-03 20:05:53 |
| chain | chain:1-960 |
| checksum | B2AA784D2D236A90 |
| comment | FUNCTION Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.SUBUNIT Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.INTERACTION Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.ALTERNATIVE PRODUCTS Widely expressed.PTM Ubiquitinated. Deubiquitinated by USP8/UBPY.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. |
| description | recommendedName: Kinesin-like protein KIF23 alternativeName: Kinesin-like protein 5 alternativeName: Mitotic kinesin-like protein 1 |
| geneName | KIF23 KNSL5 MKLP1 |
| identifier | Q02241 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell cycle Cell division Coiled coil Congenital dyserythropoietic anemia Cytoplasm Cytoskeleton Disease variant Hereditary hemolytic anemia Isopeptide bond Microtubule Mitosis Motor protein Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KIF23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000120] ENSEMBL:ENSG00000137807 KIF23 [Homo sapiens] |
| secondaryIdentifier | KIF23_HUMAN B4E1K0 Q8WVP0 |
| sequenceLength | 960 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:234364] UniProt:Q02241-2 KIF23 [Homo sapiens] [ReferenceIsoform:405062] UniProt:Q02241-1 KIF23 [Homo sapiens] [ReferenceIsoform:8969244] UniProt:Q02241-3 KIF23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:156695] p-S911,S912-KIF23 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156709] KIF23 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1015863] KIF23 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:156683] O-phospho-L-serine at 911 [ModifiedResidue:164022] O-phospho-L-serine at 912 |
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No pathways have been reviewed or authored by UniProt:Q02241 KIF23 (69908)
