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Details on Person UniProt:Q14807 KIF22
| Class:Id | ReferenceGeneProduct:69907 |
|---|---|
| _chainChangeLog | chain:1-665 added on Fri February 6 2015 |
| _displayName | UniProt:Q14807 KIF22 |
| _timestamp | 2024-11-03 20:19:41 |
| chain | chain:1-665 |
| checksum | C6C0AC96741DD387 |
| comment | FUNCTION Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).SUBUNIT Interacts with FAM83D (PubMed:18485706). Interacts with SIAH1 (PubMed:11146551).SUBCELLULAR LOCATION Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.PTM Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. |
| description | recommendedName: Kinesin-like protein KIF22 alternativeName: Kinesin-like DNA-binding protein alternativeName: Kinesin-like protein 4 |
| geneName | KIF22 KID KNSL4 |
| identifier | Q14807 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Coiled coil Cytoplasm Cytoskeleton Disease variant DNA-binding Dwarfism Isopeptide bond Microtubule Motor protein Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KIF22 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004192] ENSEMBL:ENSG00000079616 KIF22 [Homo sapiens] |
| secondaryIdentifier | KIF22_HUMAN B2R5M0 B7Z265 O60845 O94814 Q53F58 Q9BT46 |
| sequenceLength | 665 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970120] UniProt:Q14807-1 KIF22 [Homo sapiens] [ReferenceIsoform:8970121] UniProt:Q14807-2 KIF22 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:984764] KIF22 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q14807 KIF22 (69907)
