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Details on Person UniProt:O60563 CCNT1
| Class:Id | ReferenceGeneProduct:69859 |
|---|---|
| _chainChangeLog | chain:1-726 added on Fri February 6 2015 |
| _displayName | UniProt:O60563 CCNT1 |
| _timestamp | 2024-11-03 20:18:17 |
| chain | chain:1-726 |
| checksum | 4637EFB2DDEDFE13 |
| comment | FUNCTION Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539).FUNCTION (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.SUBUNIT Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb (PubMed:30134174, PubMed:35393539, PubMed:9499409). P-TEFb forms a complex with AFF4/AF5Q31 (PubMed:12065898). Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (PubMed:10393184). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts (via central region) with ZMYND8 (via N-terminus); the interaction is direct and the association appears to occur between homodimeric ZMYND8 and the activated form of the P-TEFb complex (PubMed:30134174). Interacts with BRD4, targets chromatin binding (PubMed:16109376, PubMed:16109377, PubMed:24360279). Interacts with JMJD6 (PubMed:24360279). Interacts with MDFIC (PubMed:12944466). Interacts with HSF1 (PubMed:27189267). Interacts with HTATSF1 (PubMed:10913173). Interacts with TBX21 (PubMed:27292648).SUBUNIT (Microbial infection) Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.SUBUNIT (Microbial infection) Interacts with human herpes virus 1 (HHV-1) transcriptional regulator ICP22.INTERACTION Ubiquitously expressed.DOMAIN The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance binding of the P-TEFb complex to the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).PTM ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9.SIMILARITY Belongs to the cyclin family. Cyclin C subfamily. |
| description | recommendedName: fullName evidence="24"Cyclin-T1 shortName evidence="24"CycT1 shortName: Cyclin-T |
| geneName | CCNT1 |
| identifier | O60563 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ADP-ribosylation Alternative splicing Cell cycle Cell division Coiled coil Cyclin Direct protein sequencing Host-virus interaction Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCNT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992936] ENSEMBL:ENSG00000129315 CCNT1 [Homo sapiens] |
| secondaryIdentifier | CCNT1_HUMAN A9XU13 E7EX76 O60581 |
| sequenceLength | 726 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965092] UniProt:O60563-1 CCNT1 [Homo sapiens] [ReferenceIsoform:8965093] UniProt:O60563-2 CCNT1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:51611] CCNT1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O60563 CCNT1 (69859)
