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Details on Person UniProt:P20338 RAB4A
| Class:Id | ReferenceGeneProduct:69790 |
|---|---|
| _chainChangeLog | chain:1-218 added on Sat February 7 2015 |
| _displayName | UniProt:P20338 RAB4A |
| _timestamp | 2025-08-15 22:03:38 |
| chain | chain:1-218 |
| checksum | 983D65E1162741B0 |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs).SUBUNIT Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1 (PubMed:10698684, PubMed:11786538, PubMed:11788822, PubMed:14617813, PubMed:15280022, PubMed:16034420). Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin (PubMed:17786215). Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (PubMed:20098723). Interacts with RABEP1 and RBSN (PubMed:20098723). Does not interact with HPS4 (By similarity). Interacts with RABEP2; this interaction may mediate VEGFR2 cell surface expression (PubMed:29425100).INTERACTION Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Phosphorylated by CDK1 kinase during mitosis.PTM Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.SIMILARITY Belongs to the small GTPase superfamily. Rab family.CAUTION It is uncertain whether Met-1 or Met-6 is the initiator. |
| description | recommendedName: Ras-related protein Rab-4A ecNumber evidence="19 20"3.6.5.2 |
| geneName | RAB4A RAB4 |
| identifier | P20338 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Endosome GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Methylation Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RAB4A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992089] ENSEMBL:ENSG00000168118 RAB4A [Homo sapiens] |
| secondaryIdentifier | RAB4A_HUMAN Q5T7P7 Q9BQ44 |
| sequenceLength | 218 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1458526] GGC-RAB4A [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:8871356] RAB4A [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:8873709] RAB4A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8874045] GGC-RAB4A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8875666] GGC-RAB4A [recycling endosome membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8874043] S-geranylgeranyl-L-cysteine at 216 [ModifiedResidue:8874044] S-geranylgeranyl-L-cysteine at 218 |
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No pathways have been reviewed or authored by UniProt:P20338 RAB4A (69790)
