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Details on Person UniProt:P02775 PPBP
| Class:Id | ReferenceGeneProduct:69761 |
|---|---|
| _chainChangeLog | signal peptide:1-34 added on Fri February 6 2015;chain:35-128 added on Fri February 6 2015;chain:44-128 added on Fri February 6 2015;chain:44-126 added on Fri February 6 2015;chain:44-124 added on Fri February 6 2015;chain:48-128 added on Fri February 6 2015;chain:55-128 added on Fri February 6 2015;chain:56-128 added on Fri February 6 2015;chain:59-128 added on Fri February 6 2015;chain:59-126 added on Fri February 6 2015;chain:59-124 added on Fri February 6 2015;chain:59-121 added on Fri February 6 2015 |
| _displayName | UniProt:P02775 PPBP |
| _timestamp | 2024-11-03 20:13:55 |
| chain | signal peptide:1-34 chain:35-128 chain:44-128 chain:44-126 chain:44-124 chain:48-128 chain:55-128 chain:56-128 chain:59-128 chain:59-126 chain:59-124 chain:59-121 |
| checksum | BEAB7B75916723D9 |
| comment | FUNCTION LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.SUBUNIT Beta-thromboglobulin is a homotetramer.INTERACTION Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).PTM Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.PTM NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.PTM NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.SIMILARITY Belongs to the intercrine alpha (chemokine CxC) family.ONLINE INFORMATION CXCL7 entry |
| description | recommendedName: Platelet basic protein shortName: PBP alternativeName: C-X-C motif chemokine 7 alternativeName: Leukocyte-derived growth factor shortName: LDGF alternativeName: Macrophage-derived growth factor shortName: MDGF alternativeName: Small-inducible cytokine B7 component recommendedName: Connective tissue-activating peptide III shortName: CTAP-III alternativeName: LA-PF4 alternativeName: Low-affinity platelet factor IV /component component recommendedName: TC-2 /component component recommendedName: Connective tissue-activating peptide III(1-81) shortName: CTAP-III(1-81) /component component recommendedName: Beta-thromboglobulin shortName: Beta-TG /component component recommendedName: Neutrophil-activating peptide 2(74) shortName: NAP-2(74) /component component recommendedName: Neutrophil-activating peptide 2(73) shortName: NAP-2(73) /component component recommendedName: Neutrophil-activating peptide 2 shortName: NAP-2 /component component recommendedName: TC-1 /component component recommendedName: Neutrophil-activating peptide 2(1-66) shortName: NAP-2(1-66) /component component recommendedName: Neutrophil-activating peptide 2(1-63) shortName: NAP-2(1-63) /component |
| geneName | PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1 |
| identifier | P02775 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antibiotic Antimicrobial Chemotaxis Cleavage on pair of basic residues Cytokine Direct protein sequencing Disulfide bond Growth factor Mitogen Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PPBP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994753] ENSEMBL:ENSG00000163736 PPBP [Homo sapiens] |
| secondaryIdentifier | CXCL7_HUMAN B2R5F3 Q6IBJ8 |
| sequenceLength | 128 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:114572] PPBP(35-128) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114573] PPBP(35-128) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:114637] PPBP(55-128) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114638] PPBP(55-128) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6800185] PPBP(35-128) [tertiary granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P02775 PPBP (69761)
