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Details on Person UniProt:P41208 CETN2
| Class:Id | ReferenceGeneProduct:69746 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-172 added on Fri February 6 2015;initiator methionine:1 for 69746 removed on Fri Nov 03 2023;initiator methionine: for 69746 added on Fri Nov 03 2023;initiator methionine: for 69746 removed on Fri Aug 15 2025;initiator methionine:1 for 69746 added on Fri Aug 15 2025 |
| _displayName | UniProt:P41208 CETN2 |
| _timestamp | 2025-08-15 21:13:34 |
| chain | initiator methionine:1 chain:2-172 |
| checksum | 59CFD706AD7011B5 |
| comment | FUNCTION Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.FUNCTION Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.FUNCTION The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.FUNCTION As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.SUBUNIT Monomer. Homooligomer (PubMed:15356003). Interacts with SFI1 (PubMed:16956364). Interacts with CCP110 (PubMed:16760425). Component of the XPC complex composed of XPC, RAD23B and CETN2 (PubMed:11279143, PubMed:15964821, PubMed:16533048, PubMed:16627479). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:22307388, PubMed:23591820). Interacts with USP49 (PubMed:36702832). Forms a microtubule-associated complex with POC5, POC1B and FAM161A (PubMed:32110738). Interacts with CCDC15 (PubMed:37934472).INTERACTION Localizes to the inner scaffold in the central region of centrioles and to the distal end of centrioles.MISCELLANEOUS Binds two moles of calcium per mole of protein.SIMILARITY Belongs to the centrin family. |
| description | recommendedName: Centrin-2 alternativeName: Caltractin isoform 1 |
| geneName | CETN2 CALT CEN2 |
| identifier | P41208 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Calcium Cell cycle Cell division Cytoplasm Cytoskeleton DNA damage DNA repair Isopeptide bond Metal-binding Mitosis mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Translocation Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CETN2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004595] ENSEMBL:ENSG00000147400 CETN2 [Homo sapiens] |
| secondaryIdentifier | CETN2_HUMAN B2R4T4 Q53XW1 |
| sequenceLength | 172 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:380298] CETN2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4570486] polySUMO2,3-CETN2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4570490] CETN2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9966695] CETN2 [cilium] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:4570539] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position |
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No pathways have been reviewed or authored by UniProt:P41208 CETN2 (69746)
