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Details on Person UniProt:O75688 PPM1B
| Class:Id | ReferenceGeneProduct:69724 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-479 added on Sat February 7 2015;initiator methionine:1 for 69724 removed on Fri Nov 03 2023;initiator methionine: for 69724 added on Fri Nov 03 2023;initiator methionine: for 69724 removed on Fri Aug 15 2025;initiator methionine:1 for 69724 added on Fri Aug 15 2025 |
| _displayName | UniProt:O75688 PPM1B |
| _timestamp | 2026-02-20 22:14:31 |
| chain | initiator methionine:1 chain:2-479 |
| checksum | A3A5797AD263DFBD |
| comment | FUNCTION Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.CATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateCOFACTOR Binds 2 magnesium or manganese ions per subunit.SUBUNIT Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.INTERACTION Weakly associates at the membrane and N-myristoylation mediates the membrane localization.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Highly expressed in heart and skeletal muscle.PTM Isgylation negatively regulates its activity.PTM N-myristoylation is essential for the recognition of its substrates for dephosphorylation.SIMILARITY Belongs to the PP2C family. |
| description | recommendedName: Protein phosphatase 1B ecNumber: 3.1.3.16 alternativeName: Protein phosphatase 2C isoform beta shortName: PP2C-beta |
| geneName | PPM1B PP2CB |
| identifier | O75688 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Hydrolase Isopeptide bond Lipoprotein Magnesium Manganese Membrane Metal-binding Myristate Phosphoprotein Protein phosphatase Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PPM1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992058] ENSEMBL:ENSG00000138032 PPM1B [Homo sapiens] |
| secondaryIdentifier | PPM1B_HUMAN Q461Q2 Q4J6C1 Q4J6C2 Q658R4 Q96ER6 Q9HAY8 |
| sequenceLength | 479 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151614] UniProt:O75688-2 PPM1B [Homo sapiens] [ReferenceIsoform:401887] UniProt:O75688-1 PPM1B [Homo sapiens] [ReferenceIsoform:8965753] UniProt:O75688-3 PPM1B [Homo sapiens] [ReferenceIsoform:8965754] UniProt:O75688-4 PPM1B [Homo sapiens] [ReferenceIsoform:8965755] UniProt:O75688-5 PPM1B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1169375] PPM1B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9713477] PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9713479] PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9968645] monoISG15-K12,K142-PPM1B [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9968635] ISGylated lysine (monoISG15 [cytosol]) at 142 [GroupModifiedResidue:9968637] ISGylated lysine (monoISG15 [cytosol]) at 12 |
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No pathways have been reviewed or authored by UniProt:O75688 PPM1B (69724)
