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Details on Person CHEK2 phosphorylates TP53

Class:Id	Reaction:69685
_displayName	CHEK2 phosphorylates TP53
_doRelease	TRUE
_timestamp	2022-02-22 12:56:37
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5683804] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:349474] p-S15-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:6799114] Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage [LiteratureReference:69550] DNA damage-induced activation of p53 by the checkpoint kinase Chk2. [LiteratureReference:69548] The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. [LiteratureReference:69543] Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.
modified	[InstanceEdit:143525] Schmidt, EE, 2004-11-12 05:53:46 [InstanceEdit:4332217] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:6798385] Orlic-Milacic, Marija, 2015-09-18 [InstanceEdit:6799118] Orlic-Milacic, Marija, 2015-09-21 [InstanceEdit:8856532] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8986250] Rothfels, Karen, 2017-04-24 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CHEK2 phosphorylates TP53 Phosphorylation of p53 by ATM-activated Chk2
output	[Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:5693540] MRN activates ATM [Homo sapiens] [Reaction:5682026] MRN bound to shortened telomeres activates ATM [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [Reaction:5683792] p-T68-CHEK2 autophosphorylates [Homo sapiens] [Reaction:5683774] p-T68-CHEK2 dimerizes [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens] [Reaction:349444] Phosphorylation of COP1 at Ser-387 by ATM [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:5685011] ATR activation at DNA DSBs [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860901] R-HSA-69685.4
summation	[Summation:6799111] CHEK2 (Chk2) phosphorylates TP53 (p53) at serine residue S20...
(hasEvent)	[Pathway:69541] Stabilization of p53 [Homo sapiens] [Pathway:177037] p53 mediated events [Homo sapiens] [Pathway:6804756] Regulation of TP53 Activity through Phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter [Homo sapiens] [Reaction:3215251] TP53INP1 and HIPK2 bind TP53 [Homo sapiens] [Reaction:3222093] BRD7 binds TP53 and EP300 [Homo sapiens] [Reaction:3222128] NOC2L binds TP53 [Homo sapiens] [Reaction:3222237] SMYD2 methylates TP53 [Homo sapiens] [Reaction:3700997] TP53 binds the MDM2 gene [Homo sapiens] [Reaction:3786258] TP53 binds the CDKN1A promoter [Homo sapiens] [Reaction:4331331] TP53 binds the PMAIP1 (NOXA) promoter [Homo sapiens] [Reaction:5633295] TP53 binds the NDRG1 gene promoter [Homo sapiens] [Reaction:5633414] TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes [Homo sapiens] List all 59 refering instances
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