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Details on Person UniProt:Q9NYV4 CDK12
| Class:Id | ReferenceGeneProduct:69680 |
|---|---|
| _chainChangeLog | chain:1-1490 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NYV4 CDK12 |
| _timestamp | 2025-02-21 19:57:14 |
| chain | chain:1-1490 |
| checksum | D6B04B998ECDE58E |
| comment | FUNCTION Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.SUBUNIT Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.SUBUNIT (Microbial infection) Interacts with human herpes virus 1 (HHV-1) transcriptional regulator ICP22.SUBCELLULAR LOCATION Colocalized with nuclear speckles throughout interphase.ALTERNATIVE PRODUCTS Widely expressed.PTM Phosphorylation at Thr-893 increases kinase activity.DISEASE Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Cyclin-dependent kinase 12 ecNumber: 2.7.11.22 ecNumber evidence="18"2.7.11.23 alternativeName: Cdc2-related kinase, arginine/serine-rich shortName: CrkRS alternativeName: Cell division cycle 2-related protein kinase 7 shortName: CDC2-related protein kinase 7 alternativeName: Cell division protein kinase 12 shortName: hCDK12 |
| geneName | CDK12 CRK7 CRKRS KIAA0904 |
| identifier | Q9NYV4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Chromosomal rearrangement Host-virus interaction Isopeptide bond Kinase mRNA processing mRNA splicing Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CDK12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002252] ENSEMBL:ENSG00000167258 CDK12 [Homo sapiens] |
| secondaryIdentifier | CDK12_HUMAN A7E2B2 B4DYX4 B9EIQ6 O94978 |
| sequenceLength | 1490 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:222438] UniProt:Q9NYV4-2 CDK12 [Homo sapiens] [ReferenceIsoform:414924] UniProt:Q9NYV4-1 CDK12 [Homo sapiens] [ReferenceIsoform:8965515] UniProt:Q9NYV4-3 CDK12 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6797012] CDK12 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NYV4 CDK12 (69680)
