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Details on Person In response to DNA damage due to exposure to ultraviolet (UV...
| Class:Id | Summation:69612 |
|---|---|
| _displayName | In response to DNA damage due to exposure to ultraviolet (UV... |
| _timestamp | 2025-03-10 23:39:50 |
| literatureReference | [LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9941784] The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis |
| modified | [InstanceEdit:170720] D'Eustachio, P, 2006-01-13 18:54:09 [InstanceEdit:9941616] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941788] Orlic-Milacic, Marija, 2025-03-10 |
| text | In response to DNA damage due to exposure to ultraviolet (UV) light or to ionizing radiation (IR), CDC25A is phosphorylated by CHEK1 (Chk1) or CHEK2 (Chk2). The phosphorylation of CDC25A at serine residue S123 in response to DNA damage is a signal for ubiquitination and subsequent proteasome-mediated degradation of CDC25A. The destruction of CDC25A prevents the normal G1/S transition as CDC25A is required for the activation of the Cyclin E:CDK2 (CCNE:CDK2) complexes and, to a lesser extent, Cyclin A:CDK2 (CCNA:CDK2) complexes via dephosphorylation of the tyrosine residue Y15 of CDK2 (Falck et al. 2000). Chk1 is activated in response to DNA damage due to uv light. However, the phosphorylation occurs at a different site. |
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No pathways have been reviewed or authored by In response to DNA damage due to exposure to ultraviolet (UV... (69612)
