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Details on Person Proteolytic degradation of ubiquitinated-Cdc25A

Class:IdBlackBoxEvent:69600
_displayNameProteolytic degradation of ubiquitinated-Cdc25A
_doReleaseTRUE
_timestamp2025-06-02 15:06:38
authored[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
catalystActivity[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment[Compartment:70101] cytosol
created[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
input[DefinedSet:9943733] PolyUb-p-S82-CDC25A [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05
[InstanceEdit:9953429] Rothfels, Karen, 2025-06-03
literatureReference[LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage.
[LiteratureReference:9941775] Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
[LiteratureReference:9941816] Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents
[LiteratureReference:9943730] CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation
modified[InstanceEdit:113786] Schmidt, EE, 2004-06-22 10:31:36
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:8943737] D'Eustachio, Peter, 2016-10-28
[InstanceEdit:8944696] Rothfels, Karen, 2016-11-04
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984883] Duenas, Corina, 2017-04-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9941708] Orlic-Milacic, Marija, 2025-03-10
[InstanceEdit:9941769] Orlic-Milacic, Marija, 2025-03-10
[InstanceEdit:9943744] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943976] Orlic-Milacic, Marija, 2025-04-01
[InstanceEdit:9943991] Orlic-Milacic, Marija, 2025-04-01
[InstanceEdit:9944347] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9944603] Orlic-Milacic, Marija, 2025-04-05
[InstanceEdit:9953431] Orlic-Milacic, Marija, 2025-06-02
nameProteolytic degradation of ubiquitinated-Cdc25A
output[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2004-07-06
reviewed[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360840] R-HSA-69600.5
structureModified[InstanceEdit:9941769] Orlic-Milacic, Marija, 2025-03-10
[InstanceEdit:9943744] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9953431] Orlic-Milacic, Marija, 2025-06-02
summation[Summation:179124]

Exposure of various human cell lines to ultraviolet (UV) ...

(hasEvent)[Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9749038] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A
[NegativePrecedingEvent:9749043] Incorrect Order: Proteolytic degradation of ubiquitinated-Cdc25A
[NegativePrecedingEvent:9944349] Proteolytic degradation of ubiquitinated-Cdc25A
[NegativePrecedingEvent:9944350] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A
(updatedInstance)[_UpdateTracker:9780909] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v61:[addLiteratureReference, modifyText]
[_UpdateTracker:9782460] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v59:[add_removeOutput]
[_UpdateTracker:9953720] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v93:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by Proteolytic degradation of ubiquitinated-Cdc25A (69600)
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