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Details on Person Ubiquitination of phosphorylated CDC25A

Class:Id	Reaction:69598
_displayName	Ubiquitination of phosphorylated CDC25A
_doRelease	TRUE
_timestamp	2025-06-02 15:06:49
authored	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
catalystActivity	[CatalystActivity:9941762] ubiquitin-protein transferase activity of SCF-BTrCP1,2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
input	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:9943734] p-S82-CDC25A [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05 [InstanceEdit:9953429] Rothfels, Karen, 2025-06-03
literatureReference	[LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9941757] Dual mode of degradation of Cdc25 A phosphatase [LiteratureReference:9941775] Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage [LiteratureReference:9941822] SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase [LiteratureReference:9942659] Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation
modified	[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00 [InstanceEdit:113786] Schmidt, EE, 2004-06-22 10:31:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984615] Duenas, Corina, 2017-04-10 [InstanceEdit:9749041] Matthews, Lisa, 2021-07-29 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941617] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941758] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941769] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941780] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9941826] Orlic-Milacic, Marija, 2025-03-11 [InstanceEdit:9942661] Orlic-Milacic, Marija, 2025-03-18 [InstanceEdit:9943744] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9943976] Orlic-Milacic, Marija, 2025-04-01 [InstanceEdit:9944344] Orlic-Milacic, Marija, 2025-04-04 [InstanceEdit:9944346] Orlic-Milacic, Marija, 2025-04-04 [InstanceEdit:9944347] Orlic-Milacic, Marija, 2025-04-04 [InstanceEdit:9953431] Orlic-Milacic, Marija, 2025-06-02
name	Ubiquitination of phosphorylated CDC25A
negativePrecedingEvent	[NegativePrecedingEvent:9749042] Abundant Molecules: Proteasome mediated degradation of COP1 [NegativePrecedingEvent:9749043] Incorrect Order: Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9766477] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53
output	[DefinedSet:9943733] PolyUb-p-S82-CDC25A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9943736] Casein kinase I phosphorylates CDC25A [Homo sapiens] [BlackBoxEvent:9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A [Homo sapiens] [Reaction:9943675] GSK3B phosphorylates CDC25A [Homo sapiens] [Reaction:69604] Phosphorylation of CDC25A by CHEK1 [Homo sapiens] [Reaction:9942578] Phosphorylation of CDC25A by p38 MAPK [Homo sapiens] [Reaction:9943676] NEK11 phosphorylates CDC25A [Homo sapiens] [BlackBoxEvent:9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A [Homo sapiens] [Reaction:9943662] CHEK1 phosphorylates NEK11 [Homo sapiens] [Reaction:9943675] GSK3B phosphorylates CDC25A [Homo sapiens] [Reaction:69604] Phosphorylation of CDC25A by CHEK1 [Homo sapiens] [Reaction:9942578] Phosphorylation of CDC25A by p38 MAPK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358406] R-HSA-69598.7
structureModified	[InstanceEdit:9941769] Orlic-Milacic, Marija, 2025-03-10 [InstanceEdit:9943744] Orlic-Milacic, Marija, 2025-03-31 [InstanceEdit:9953431] Orlic-Milacic, Marija, 2025-06-02
summation	[Summation:179284] Exposure of various human cell lines to ultraviolet (UV) ...
(hasEvent)	[Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781275] Update Tracker - [Reaction:69598] Ubiquitination of phosphorylated Cdc25A - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9953757] Update Tracker - [Reaction:69598] Ubiquitination of phosphorylated CDC25A - v93:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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