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Details on Person MDM2 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:69486
_displayName	MDM2 [nucleoplasm]
_timestamp	2013-02-06 16:58:25
compartment	[Compartment:7660] nucleoplasm
endCoordinate	491
modified	[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:157475] Matthews, L, 2004-12-30 22:27:31 [InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3132750] Wu, G, 2013-02-13
name	MDM2 Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2) Ubiquitin-protein ligase E3 Mdm2 p53-binding protein Mdm2 Oncoprotein Mdm2 Double minute 2 protein Hdm2
referenceEntity	[ReferenceGeneProduct:95018] UniProt:Q00987 MDM2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:364336] R-HSA-69486.1
startCoordinate	1
(activeUnit)	[CatalystActivity:2997569] SUMO transferase activity of p14-ARF:MDM2 [nucleoplasm] [CatalystActivity:3209190] ubiquitin-protein transferase activity of MDM2:TP53 [nucleoplasm]
(hasComponent)	[Complex:69489] MDM2:TP53 [nucleoplasm] [Homo sapiens] [Complex:3209192] p14-ARF:MDM2 [nucleoplasm] [Homo sapiens] [Complex:3215303] Ub:MDM2 [nucleoplasm] [Homo sapiens]
(hasMember)	[DefinedSet:5689965] MDM2,MDM4 [nucleoplasm] [Homo sapiens] [DefinedSet:5689977] TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] [Homo sapiens]
(input)	[Reaction:3000434] PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 [Homo sapiens] [Reaction:5228523] RANBP2 SUMOylates MDM2 with SUMO1 [Homo sapiens] [Reaction:6795667] MDM2 translocates to the cytosol [Homo sapiens]
(output)	[BlackBoxEvent:3700992] TP53 stimulates MDM2 transcription [Homo sapiens] [BlackBoxEvent:5628884] TP53 and BRD7 positively regulate expression of TP53 targets [Homo sapiens] [Reaction:6792863] PP2A-PP2R5C dephosphorylates MDM2 [Homo sapiens]
(physicalEntity)	[CatalystActivity:9977106] ubiquitin protein ligase activity of MDM2 [nucleoplasm]
(updatedInstance)	[_UpdateTracker:9878635] Update Tracker - [EntityWithAccessionedSequence:69486] MDM2 [nucleoplasm] - v44:[modifyEndCoordinate, modifyName]
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No pathways have been reviewed or authored by MDM2 [nucleoplasm] (69486)