Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes

Class:IdReaction:69227
_displayNameCyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
_doReleaseTRUE
_timestamp2024-03-06 02:45:46
authored[InstanceEdit:113706] Matthews, L, 2004-06-19 02:00:00
catalystActivity[CatalystActivity:182511] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643320] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
compartment[Compartment:7660] nucleoplasm
edited[InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
figure[Figure:69228] /figures/Cdk46_RbP.jpg
input[SimpleEntity:29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9856496] D'Eustachio, Peter, 2023-12-18
literatureReference[LiteratureReference:113709] Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
[LiteratureReference:9687301] Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
[LiteratureReference:9687300] Cumulative effect of phosphorylation of pRB on regulation of E2F activity
[LiteratureReference:9687329] Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
[LiteratureReference:9687325] Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein
[LiteratureReference:9687293] Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo
[LiteratureReference:9687305] Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
[LiteratureReference:9687327] Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
[LiteratureReference:9687302] A Code of Mono-phosphorylation Modulates the Function of RB
modified[InstanceEdit:112170] Matthews, L, 0000-00-00 00:00:00
[InstanceEdit:113706] Matthews, L, 2004-06-19 02:00:00
[InstanceEdit:141302] Gopinathrao, G, 2004-09-14 11:08:02
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:182499] Matthews, L, 2006-07-10 14:41:36
[InstanceEdit:182624] Matthews, L, 2006-07-11 10:43:36
[InstanceEdit:182701] Matthews, L, 2006-07-12 15:07:56
[InstanceEdit:184183] Matthews, L, 2006-07-26 22:28:14
[InstanceEdit:213369] Matthews, L, 2008-02-26 00:56:34
[InstanceEdit:1227908] Orlic-Milacic, Marija, 2011-03-10
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8949904] Orlic-Milacic, Marija, 2016-11-30
[InstanceEdit:9018022] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9687332] Orlic-Milacic, Marija, 2020-05-07
[InstanceEdit:9687375] Orlic-Milacic, Marija, 2020-05-07
[InstanceEdit:9688866] Orlic-Milacic, Marija, 2020-05-15
[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
[InstanceEdit:9709080] Matthews, Lisa, 2020-12-07
[InstanceEdit:9757609] Orlic-Milacic, Marija, 2021-11-02
[InstanceEdit:9758285] Orlic-Milacic, Marija, 2021-11-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9856135] Orlic-Milacic, Marija, 2023-12-11
[InstanceEdit:9856136] Orlic-Milacic, Marija, 2023-12-11
[InstanceEdit:9856139] Orlic-Milacic, Marija, 2023-12-11
[InstanceEdit:9863933] Matthews, Lisa, 2024-03-06
nameCyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
output[DefinedSet:9687348] monophosphorylated RB1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:9757606] Negative regulation by 'p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm]'
[NegativeRegulation:9757607] Negative regulation by 'p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm]'
releaseDate2004-07-06
reviewed[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
[InstanceEdit:9757975] Kadambat Nair, Sisira, 2021-11-02
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360123] R-HSA-69227.10
structureModified[InstanceEdit:9856135] Orlic-Milacic, Marija, 2023-12-11
[InstanceEdit:9856136] Orlic-Milacic, Marija, 2023-12-11
summation[Summation:213349] CDK4 and CDK6, in complex with D type cyclins (CCND1, CCND2 ...
(hasEvent)[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(precedingEvent)[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
[BlackBoxEvent:113498] Activation of Cdc25a (string) by E2F1 [Homo sapiens]
[Reaction:113503] PP2A mediated localization of RB1 protein in chromatin [Homo sapiens]
[BlackBoxEvent:113610] Activation of PolA catalytic subunit by E2F1 [Homo sapiens]
[BlackBoxEvent:113621] Activation of Cdc45 by E2F1 [Homo sapiens]
[BlackBoxEvent:113622] Activation of Cyclin E by E2F1 [Homo sapiens]
[BlackBoxEvent:113625] Activation of Cdt1 by E2F1 [Homo sapiens]
[BlackBoxEvent:113632] Expression of ORC1 [Homo sapiens]
[Reaction:188386] Association of Rb with Cyclin E:Cdk2 complexes [Homo sapiens]
[Reaction:3209096] E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter [Homo sapiens]
List all 27 refering instances
(updatedInstance)[_UpdateTracker:9775369] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v79:[addRegulator]
[_UpdateTracker:9776994] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v73:[addLiteratureReference, add_removeOutput, modifyText]
[_UpdateTracker:9780238] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v63:[add_removeInput, removeOutput]
[_UpdateTracker:9788748] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v40:[modifyText]
[_UpdateTracker:9789792] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v37:[add_removeOutput]
[_UpdateTracker:9792024] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v24:[addSummation]
[Change default viewing format]
No pathways have been reviewed or authored by Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (69227)
Follow Reactome