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| Class:Id | PathwayDiagram:692064 |
|---|---|
| _displayName | Diagram of Host Interactions of HIV factors |
| _timestamp | 2020-07-22 17:27:41 |
| created | [InstanceEdit:692063] Gillespie, ME, 2010-05-07 |
| height | 1366 |
| modified | [InstanceEdit:708357] Gillespie, ME, 2010-05-11 [InstanceEdit:1571945] Gillespie, ME, 2011-09-07 [InstanceEdit:1929420] Gillespie, ME, 2011-11-02 [InstanceEdit:1946653] Gillespie, ME, 2011-11-03 [InstanceEdit:3059092] Jupe, S, 2013-02-06 [InstanceEdit:3076343] Gillespie, ME, 2013-02-06 [InstanceEdit:5545495] Matthews, Lisa, 2014-05-22 [InstanceEdit:5678594] Matthews, Lisa, 2015-02-24 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:9638001] D'Eustachio, Peter, 2019-02-22 [InstanceEdit:9638005] D'Eustachio, Peter, 2019-02-22 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9696552] D'Eustachio, Peter, 2020-07-22 |
| representedPathway | [Pathway:162909] Host Interactions of HIV factors [Homo sapiens] |
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41 22" textPosition="751 140"> <Properties> <displayName>CD28</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="131" reactomeId="167629" position="866 150" bounds="805 139 123 22" textPosition="806 140" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Nef:CD28 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="134" reactomeId="167585" position="1001 147" bounds="943 129 116 36" textPosition="977 136"> <Properties> <displayName>AP2M1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="135" reactomeId="167636" position="1144 150" bounds="1079 125 131 50" textPosition="1083 126" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD28:Nef:Clathrin-coated Pit Adapter Protein Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="137" reactomeId="167631" position="1148 254" bounds="1083 229 131 50" textPosition="1087 230" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD28:Nef:Clathrin-coated Pit Adapter Protein</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="139" reactomeId="182275" position="803 340" bounds="740 322 127 36" textPosition="764 323" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>class I MHC complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="140" reactomeId="182256" position="625 325" bounds="574 307 102 36" textPosition="574 308" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Nef:class I MHC complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="144" reactomeId="17963" position="701 387" bounds="542 330 319 114" textPosition="716 402" bgColor="250 240 240" lineColor="255 153 102" insets="552 340 299 94"> <Properties> <displayName>Golgi lumen</displayName> </Properties> <Components> <Component id="139" /> <Component id="140" /> <Component id="148" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="146" reactomeId="167634" position="593 283" bounds="567 272 52 22" textPosition="570 272"> <Properties> <displayName>PACS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="147" reactomeId="167717" position="443 339" bounds="394 328 99 22" textPosition="397 329" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AP-1 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="148" reactomeId="182373" position="589 414" bounds="535 389 109 50" textPosition="535 390" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Nef:class I MHC complex:Ap-1:PACS-1 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="150" reactomeId="182254" position="358 386" bounds="304 361 109 50" textPosition="304 362" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Nef:class I MHC complex:AP-1:PACS-1 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="152" reactomeId="171062" position="291 431" bounds="184 361 215 141" textPosition="187 464" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="150" /> <Component id="162" /> <Component id="166" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="154" reactomeId="167529" position="682 148" bounds="625 137 114 22" textPosition="626 138" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CD4:Lck Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="155" reactomeId="167596" position="551 144" bounds="494 133 115 22" textPosition="495 134" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD4:Nef Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="156" reactomeId="167609" position="515 211" bounds="493 199 45 24" textPosition="500 200" /> <org.gk.render.RenderableComplex id="158" reactomeId="167712" position="416 225" bounds="367 214 98 22" textPosition="369 215" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="159" reactomeId="167602" position="414 141" bounds="382 130 64 22" textPosition="383 130" /> <org.gk.render.RenderableComplex id="160" reactomeId="167544" position="259 139" bounds="198 114 123 50" textPosition="198 115" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD4:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="162" reactomeId="167554" position="226 374" bounds="162 342 128 64" textPosition="161 343" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="164" reactomeId="167542" position="602 526" bounds="586 515 33 22" textPosition="586 515"> <Properties> <displayName>CD4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="165" reactomeId="200826" position="695 465" bounds="674 454 42 22" textPosition="676 454"> <Properties> <displayName>ARF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="166" reactomeId="200867" position="415 473" bounds="351 455 128 36" textPosition="351 456" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Arf1:Nef:endosomal CD4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="171" reactomeId="167578" position="321 225" bounds="289 214 64 22" textPosition="290 214" /> <org.gk.render.RenderableComplex id="173" reactomeId="182194" position="103 708" bounds="46 697 115 22" textPosition="47 698" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD8:Nef Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="174" reactomeId="182158" position="134 791" bounds="73 766 123 50" textPosition="73 767" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD8:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="175" reactomeId="167602" position="126 642" bounds="94 631 64 22" textPosition="95 631"> <Properties> <displayName>ATP6V1H</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="179" reactomeId="167712" position="224 647" bounds="173 636 103 22" textPosition="178 637" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="181" reactomeId="182230" position="259 922" bounds="195 890 128 64" textPosition="194 891" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="182" reactomeId="171062" position="302 949" bounds="235 873 135 152" textPosition="251 974" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>early endosome membrane</displayName> </Properties> <Components> <Component id="181" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="191" reactomeId="180575" position="1048 383" bounds="1032 372 33 22" textPosition="1032 372" /> <org.gk.render.RenderableComplex id="192" reactomeId="180601" position="1158 382" bounds="1100 371 117 22" textPosition="1102 372" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD4:Vpu complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="196" reactomeId="17957" position="1152 449" bounds="892 378 520 143" textPosition="915 438" bgColor="250 240 240" lineColor="255 153 102" insets="902 388 500 123"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="191" /> <Component id="192" /> <Component id="189" /> <Component id="199" /> <Component id="202" /> <Component id="204" /> <Component id="205" /> <Component id="206" /> <Component id="223" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="198" reactomeId="174237" position="1145 326" bounds="1111 315 68 22" textPosition="1126 315"> <Properties> <displayName>BTRC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="199" reactomeId="180532" position="1296 386" bounds="1248 368 97 36" textPosition="1248 369" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD4:Vpu:beta-TrCP_1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="201" reactomeId="174150" position="1292 313" bounds="1272 302 40 22" textPosition="1274 302"> <Properties> <displayName>SKP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="202" reactomeId="180592" position="1408 391" bounds="1360 366 97 50" textPosition="1360 367" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>CD4:Vpu:beta-TrCP_1:Skp1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="204" reactomeId="180530" position="1366 475" bounds="1308 443 116 64" textPosition="1307 444" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="206" reactomeId="180567" position="1038 508" bounds="983 490 110 36" textPosition="985 491" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>Vpu:beta-TrCP1:Skp1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="207" reactomeId="68819" position="1352 541" bounds="1296 530 113 22" textPosition="1301 531" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>26S proteasome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="209" reactomeId="113571" position="1372 818" bounds="1351 803 43 30" textPosition="1357 807"> <Properties> <displayName>GTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="210" reactomeId="180701" position="1365 874" bounds="1333 863 65 22" textPosition="1335 864" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ran-GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="211" reactomeId="111349" position="1149 805" bounds="1128 790 43 30" textPosition="1133 794"> <Properties> <displayName>GDP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="212" reactomeId="180690" position="1259 793" bounds="1238 782 42 22" textPosition="1239 782"> <Properties> <displayName>RCC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="213" reactomeId="3008211" position="620 779" bounds="573 768 95 22" textPosition="600 768"> <Properties> <displayName>NPM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="214" reactomeId="606320" position="1481 874" bounds="1434 863 95 22" textPosition="1461 863" /> <org.gk.render.RenderableProtein id="215" reactomeId="175380" position="1095 980" bounds="1033 962 124 36" textPosition="1050 962"> <Properties> <displayName>REV (P04618) protein</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="216" reactomeId="173267" position="482 1229" bounds="420 1211 124 36" textPosition="437 1211" /> <org.gk.render.RenderableProtein id="217" reactomeId="198166" position="1831 145" bounds="1770 127 122 36" textPosition="1800 134"> <Properties> <displayName>CD247-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="218" reactomeId="173193" position="1808 1009" bounds="1756 991 105 36" textPosition="1793 998"> <Properties> <displayName>VPR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="219" reactomeId="180888" position="1806 842" bounds="1754 824 105 36" textPosition="1791 831" /> <org.gk.render.RenderableProtein id="220" reactomeId="173256" position="715 690" bounds="666 672 99 36" textPosition="672 672"> <Properties> <displayName>VIF (P69723) protein</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="221" reactomeId="175856" position="1414 714" bounds="1365 703 99 22" textPosition="1373 703"> <Properties> <displayName>Tat (P04608)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="222" reactomeId="167605" position="1611 228" bounds="1550 212 123 33" textPosition="1557 218"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.14227642276422764" relativeY="0.0" label="My" trackId="0" reactomeId="167595" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="223" reactomeId="180550" position="945 384" bounds="894 373 102 22" textPosition="901 373"> <Properties> <displayName>VPU (P05919)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="225" reactomeId="167712" position="261 1187" bounds="215 1176 93 22" textPosition="231 1163" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AP-2 Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="227" reactomeId="167578" position="208 1113" bounds="176 1102 64 22" textPosition="177 1102" /> <org.gk.render.RenderableProtein id="228" reactomeId="167605" position="449 899" bounds="390 882 118 35" textPosition="394 889"> <Properties> <displayName>myristoylated nef</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1483050847457627" relativeY="0.0" label="My" trackId="0" reactomeId="167595" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="230" reactomeId="167605" position="772 490" bounds="714 474 116 33" textPosition="717 480"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.15086206896551724" relativeY="0.0" label="My" trackId="0" reactomeId="167595" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="232" reactomeId="167605" position="710 204" bounds="652 190 117 29" textPosition="656 194"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.14957264957264957" relativeY="0.0" label="My" trackId="0" reactomeId="167595" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="233" reactomeId="442615" position="1851 365" bounds="1831 354 41 22" textPosition="1831 354"> <Properties> <displayName>RAC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="236" reactomeId="51801" position="1086 720" bounds="1065 709 42 22" textPosition="1065 709"> <Properties> <displayName>CDK9</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="237" reactomeId="51611" position="1073 774" bounds="1048 763 50 22" textPosition="1048 763"> <Properties> <displayName>CCNT1</displayName> </Properties> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="1" reactomeId="180855" points="1809 988, 1812 940, 1807 863" position="1812 940" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="218" /> </Inputs> <Outputs> <Output id="219" /> </Outputs> <Properties> <displayName>Translocation of Vpr to the mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4" reactomeId="180905" points="1823 735, 1821 694, 1791 677" position="1821 694" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="219" points="1808 821" /> <Input id="5" points="1803 734" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> <Properties> <displayName>Association of Vpr with ANT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="180622" points="860 952, 880 972, 927 1021" position="880 972" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14" points="916 909" /> <Input id="15" points="812 916" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>Vpr binds nucleoporins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="180627" points="681 939, 681 978, 680 1010" position="681 978" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="19" points="652 907" /> <Input id="15" points="732 916" /> </Inputs> <Outputs> <Output id="20" /> </Outputs> <Properties> <displayName>Interaction of Vpr with importin alpha</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="180709" points="552 879, 548 780, 576 737" position="548 780" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="25" points="488 1051" /> <Input id="26" points="593 931" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> <Properties> <displayName>Association of multimerized Rev with beta-importin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="28" reactomeId="180725" points="638 747, 673 747, 712 744" position="673 747" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="27" points="616 737" /> <Input id="213" points="626 765" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>Rev associates with B23</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="180710" points="807 786, 833 778, 876 762" position="833 778" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="30" points="786 761" /> <Input id="14" points="914 867" /> </Inputs> <Outputs> <Output id="35" /> </Outputs> <Properties> <displayName>Rev:importin beta:B23 recruited to the nuclear pore</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="39" reactomeId="180732" points="988 778, 1019 795, 1021 829" position="1019 795" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="35" /> </Inputs> <Outputs> <Output id="40" points="1069 902" /> <Output id="14" points="963 867" /> </Outputs> <Properties> <displayName>Translocation of Rev:importin-beta:B23 to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="180728" points="1169 921, 1207 921, 1236 920" position="1207 921" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="40" points="1143 921" /> <Input id="42" points="1135 879" /> </Inputs> <Outputs> <Output id="43" /> </Outputs> <Properties> <displayName>Association of Ran-GTP with importin-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="180736" points="1360 921, 1382 922, 1408 922" position="1382 922" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="46" points="1440 923" /> <Output id="47" points="1428 966" /> <Output id="214" points="1464 888" /> </Outputs> <Properties> <displayName>Disassembly of the Rev-importin beta-B23:Ran-GTP complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="48" reactomeId="165027" points="1166 1001, 1194 991, 1218 988" position="1194 991" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="50" points="1151 1011" /> <Input id="215" points="1155 998" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Properties> <displayName>Rev molecules assemble onto the RRE RNA sequence through their ARM sequence</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="165033" points="1315 1016, 1298 1036, 1280 1064" position="1298 1036" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="51" points="1299 1005" /> <Input id="47" points="1396 994" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Properties> <displayName>Multimerization of Rev</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="180885" points="1413 1077, 1440 1078, 1470 1079" position="1440 1078" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="55" points="1447 1038" /> <Input id="53" points="1340 1081" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA associates with Crm1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="165034" points="1390 1140, 1315 1142, 1275 1142" position="1315 1142" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="56" points="1475 1109" /> <Input id="59" points="1435 1161" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="60" reactomeId="165043" points="1105 1140, 1071 1140, 1046 1138" position="1071 1140" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="14" points="948 909, 1055 1092" /> <Input id="58" points="1137 1140" /> </Inputs> <Outputs> <Output id="61" /> </Outputs> <Properties> <displayName>Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="62" reactomeId="165047" points="908 1138, 884 1139, 864 1139" position="884 1139" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="61" /> </Inputs> <Outputs> <Output id="14" points="938 909, 938 948, 864 1014" /> <Output id="63" points="837 1138" /> </Outputs> <Properties> <displayName>Translocation of nuclear RNA transport complex to cytoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="180739" points="764 1188, 722 1188, 652 1141" position="722 1188" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="65" points="885 1188" /> <Input id="63" points="766 1166" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Properties> <displayName>Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="67" reactomeId="165028" points="620 1141, 624 1170, 634 1233" position="624 1170" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="25" points="494 1079" /> <Output id="216" points="547 1230" /> <Output id="69" points="429 1172" /> <Output id="68" points="553 1260" /> <Output id="71" points="450 1138" /> <Output id="65" points="885 1192" /> </Outputs> <Properties> <displayName>Release of the HIV mRNA and Crm1 from Rev in the cytoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="165055" points="553 1270, 711 1268, 711 1294" position="711 1268" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="68" /> </Inputs> <Outputs> <Output id="76" points="748 1306" /> <Output id="77" points="673 1299" /> </Outputs> <Catalysts> <Catalyst id="63" points="757 1166" /> </Catalysts> <Activators> <Activator id="78" points="955 1253" /> <Activator id="65" points="888 1202" /> </Activators> <Properties> <displayName>Hydrolysis of Ran:GTP to Ran:GDP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="180630" points="430 836, 394 836, 367 835" position="394 836" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="80" points="465 684" /> <Input id="15" points="780 860, 778 833" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Inhibitors> <Inhibitor id="91" points="819 635, 561 640" /> </Inhibitors> <Properties> <displayName>Association of APOBEC3G with Gag</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="180634" points="367 678, 342 655, 320 627" position="342 655" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="80" points="425 671" /> <Input id="83" points="354 685" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="180632" points="419 591, 469 592, 516 591" position="469 592" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="84" points="366 591" /> <Input id="86" points="408 607" /> </Inputs> <Outputs> <Output id="87" points="616 588" /> <Output id="88" points="521 610" /> </Outputs> <Catalysts> <Catalyst id="80" points="468 650" /> </Catalysts> <Properties> <displayName>Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="180602" points="639 648, 772 645, 819 639" position="772 645" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="80" points="512 662" /> <Input id="220" points="682 669" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>Association of Vif with APOBEC3G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="180555" points="971 637, 1004 637, 1032 638" position="1004 637" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="91" points="919 635" /> <Input id="96" points="930 606" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Properties> <displayName>Association of APOBEC3G:Vif with the Cul5-SCF complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="180540" points="1228 639, 1282 639, 1309 639" position="1282 639" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" stoichiometry="3" points="1335 597" /> <Input id="97" points="1162 640" /> </Inputs> <Outputs> <Output id="100" /> </Outputs> <Catalysts> <Catalyst id="97" points="1162 655, 1180 660, 1280 660" /> </Catalysts> <Properties> <displayName>Multi-ubiquitination of APOBEC3G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="180603" points="1445 636, 1482 635, 1484 593" position="1482 635" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="100" /> </Inputs> <Outputs> <Output id="102" points="1504 579" /> <Output id="99" stoichiometry="3" points="1405 588" /> </Outputs> <Catalysts> <Catalyst id="103" points="1523 634" /> </Catalysts> <Properties> <displayName>Proteosome-mediated degradation of APOBEC3G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="167234" points="1393 753, 1442 753, 1478 753" position="1442 753" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="221" points="1408 728" /> <Input id="105" points="1346 753" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> <Properties> <displayName>Association of Tat with P-TEFb(Cyclin T1:Cdk9)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="109" reactomeId="164943" points="1695 192, 1771 194, 1805 194" position="1771 194" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="110" points="1652 185" /> <Input id="222" points="1649 209" /> <Input id="112" points="1708 156" /> <Input id="217" points="1778 166" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Properties> <displayName>Nef mediated activation of the T-cell receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="200858" points="1542 291, 1566 311, 1565 341" position="1566 311" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="222" points="1592 248" /> <Input id="116" points="1520 293" /> </Inputs> <Outputs> <Output id="117" /> </Outputs> <Properties> <displayName>Nef Binds and activates the Src-family tyrosine kinase Hck</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="118" reactomeId="200908" points="1478 228, 1444 228, 1388 228" position="1444 228" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="119" points="1491 201" /> <Input id="222" points="1547 228" /> </Inputs> <Outputs> <Output id="120" /> </Outputs> <Properties> <displayName>Nef Binds and activates the Src-family tyrosine kinase Fyn</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="200954" points="1648 324, 1639 349, 1637 378" position="1639 349" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="122" points="1669 331" /> <Input id="222" points="1617 248" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Properties> <displayName>Nef Binds and activates the Src-family tyrosine kinase Lck</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="200952" points="1745 343, 1750 367, 1750 411" position="1750 367" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="127" points="1807 314" /> <Input id="233" points="1828 360" /> <Input id="125" points="1781 295" /> <Input id="222" points="1630 248" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="129" reactomeId="167630" points="784 186, 814 187, 850 164" position="814 187" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="130" points="775 165" /> <Input id="232" points="769 187" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Properties> <displayName>Formation of Nef CD28 cytoplasmic tail complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="133" reactomeId="167633" points="909 178, 1045 179, 1076 169" position="1045 179" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="134" points="947 168" /> <Input id="131" points="882 164" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Properties> <displayName>Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="167637" points="1145 178, 1147 203, 1147 226" position="1147 203" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="135" /> </Inputs> <Outputs> <Output id="137" /> </Outputs> <Properties> <displayName>Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="138" reactomeId="182243" points="759 314, 727 303, 679 314" position="727 303" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="139" points="772 319" /> <Input id="232" points="716 222" /> </Inputs> <Outputs> <Output id="140" /> </Outputs> <Properties> <displayName>Formation of MHC I:Nef Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="145" reactomeId="182279" points="516 316, 518 349, 561 386" position="518 349" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="146" points="567 297" /> <Input id="147" points="477 325" /> <Input id="140" points="571 320" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Properties> <displayName>Formation of MHC I:Nef:AP-1:PACS-1 Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="182286" points="532 412, 479 411, 416 397" position="479 411" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="148" /> </Inputs> <Outputs> <Output id="150" /> </Outputs> <Properties> <displayName>Transport of MHC I:Nef:AP-1:PACS-1 Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="182263" points="356 358, 355 325, 421 296" position="355 325" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="150" /> </Inputs> <Outputs> <Output id="146" points="564 284" /> <Output id="147" points="437 325" /> <Output id="232" points="664 222" /> </Outputs> <Properties> <displayName>Degradation of MHC I Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="167566" points="646 181, 616 197, 579 197" position="616 197" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="154" points="670 162" /> <Input id="232" points="669 187" /> </Inputs> <Outputs> <Output id="155" points="556 158" /> <Output id="156" points="541 206" /> </Outputs> <Properties> <displayName>Nef mediated disruption of CD4:Lck Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="157" reactomeId="167537" points="405 177, 351 177, 319 167" position="351 177" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="158" points="413 211" /> <Input id="155" points="502 158" /> <Input id="159" points="411 155" /> </Inputs> <Outputs> <Output id="160" /> </Outputs> <Properties> <displayName>Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="167597" points="257 167, 253 219, 231 339" position="253 219" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="160" /> </Inputs> <Outputs> <Output id="162" /> </Outputs> <Properties> <displayName>Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="163" reactomeId="200879" points="590 476, 557 471, 525 471, 482 471" position="525 471" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="164" points="599 512" /> <Input id="165" points="671 467" /> <Input id="230" points="711 485" /> </Inputs> <Outputs> <Output id="166" /> </Outputs> <Properties> <displayName>Formation of a Nef:ARF1:CD4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="167601" points="268 339, 324 300, 323 270" position="324 300" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="162" /> </Inputs> <Outputs> <Output id="158" points="393 239" /> <Output id="171" points="321 239" /> <Output id="232" points="649 213" /> </Outputs> <Properties> <displayName>Degradation of CD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="182186" points="182 678, 162 731, 145 763" position="162 731" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="173" points="131 694" /> <Input id="175" points="143 656" /> <Input id="179" points="209 661" /> </Inputs> <Outputs> <Output id="174" /> </Outputs> <Properties> <displayName>Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="180" reactomeId="182198" points="154 819, 186 855, 224 887" position="186 855" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="174" /> </Inputs> <Outputs> <Output id="181" /> </Outputs> <Properties> <displayName>Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="183" reactomeId="182171" points="255 957, 246 1057, 267 1071" position="246 1057" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="181" /> </Inputs> <Outputs> <Output id="225" points="261 1173" /> <Output id="227" points="223 1099" /> <Output id="228" points="441 920, 389 1038" /> </Outputs> <Properties> <displayName>Degradation of CD8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="180606" points="1070 410, 1092 423, 1140 396" position="1092 423" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="191" points="1056 397" /> <Input id="223" points="999 394" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>Association of Vpu with CD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="197" reactomeId="180591" points="1183 350, 1219 349, 1258 365" position="1219 349" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="198" points="1162 340" /> <Input id="192" points="1166 368" /> </Inputs> <Outputs> <Output id="199" /> </Outputs> <Properties> <displayName>Vpu:CD4 associates with beta-TrCP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="180599" points="1334 338, 1381 338, 1395 363" position="1381 338" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="199" points="1310 365" /> <Input id="201" points="1310 327" /> </Inputs> <Outputs> <Output id="202" /> </Outputs> <Properties> <displayName>The Vpu:CD4:beta-TrCP complex recruits SKP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="203" reactomeId="180597" points="1475 476, 1452 476, 1427 475" position="1452 476" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="99" stoichiometry="3" points="1385 570, 1475 514" /> <Input id="202" points="1460 388, 1476 387" /> </Inputs> <Outputs> <Output id="204" /> </Outputs> <Catalysts> <Catalyst id="202" points="1420 419" /> </Catalysts> <Properties> <displayName>Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="205" reactomeId="180573" points="1305 492, 1252 509, 1154 508" position="1252 509" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="204" /> </Inputs> <Outputs> <Output id="99" stoichiometry="3" points="1335 576" /> <Output id="206" points="1096 508" /> </Outputs> <Catalysts> <Catalyst id="207" points="1317 527" /> </Catalysts> <Properties> <displayName>Degradation of ubiquitinated CD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="180687" points="1304 846, 1260 845, 1193 846" position="1260 845" lineWidth="1.0"> <Inputs> <Input id="209" points="1348 826" /> <Input id="210" points="1341 860" /> </Inputs> <Outputs> <Output id="211" points="1165 823" /> <Output id="42" points="1161 856" /> </Outputs> <Catalysts> <Catalyst id="212" points="1259 807" /> </Catalysts> <Properties> <displayName>Conversion of Ran-GDP to Ran-GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="235" reactomeId="167235" points="1120 748, 1177 748, 1226 750" position="1177 748" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="236" points="1099 734" /> <Input id="237" points="1092 760" /> </Inputs> <Outputs> <Output id="105" /> </Outputs> <Properties> <displayName>Formation of the P-TEFb(Cyclin T1:Cdk9) complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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