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Details on Person The loading of proliferating cell nuclear antigen (PCNA) lea...
| Class:Id | Summation:69075 |
|---|---|
| _displayName | The loading of proliferating cell nuclear antigen (PCNA) lea... |
| _timestamp | 2019-12-01 13:53:19 |
| literatureReference | [LiteratureReference:8984443] Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8 |
| modified | [InstanceEdit:8863074] D'Eustachio, Peter, 2016-03-03 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9668890] Orlic-Milacic, Marija, 2019-12-01 |
| text | The loading of proliferating cell nuclear antigen (PCNA) leads to recruitment of pol delta, the process of polymerase switching. Human PCNA is a homotrimer of 36 kDa subunits that form a toroidal structure. The loading of PCNA by RFC is a key event in the transition from the priming mode to the extension mode of DNA synthesis. The processive complex is composed of the pol delta holoenzyme and PCNA (Murakami et al.2010). Both PCNA and the DNA polymerase delta are needed for telomeric C-strand synthesis in a human telomere replication model (Lormand et al. 2013). |
| (summation) | [Reaction:69074] Formation of Processive Complex [Homo sapiens] |
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No pathways have been reviewed or authored by The loading of proliferating cell nuclear antigen (PCNA) lea... (69075)
