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Details on Person The binding of the primer recognition complex involves the l...
| Class:Id | Summation:69064 |
|---|---|
| _displayName | The binding of the primer recognition complex involves the l... |
| _timestamp | 2020-05-04 18:59:19 |
| literatureReference | [LiteratureReference:69065] Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin. [LiteratureReference:69067] Clamping down on clamps and clamp loaders--the eucaryotic replication factor C. |
| modified | [InstanceEdit:9668887] Orlic-Milacic, Marija, 2019-11-30 [InstanceEdit:9671187] Orlic-Milacic, Marija, 2019-12-18 [InstanceEdit:9672905] Orlic-Milacic, Marija, 2020-01-03 [InstanceEdit:9686634] Orlic-Milacic, Marija, 2020-05-04 |
| text | The binding of the primer recognition complex involves the loading of the proliferating cell nuclear antigen (PCNA). Replication Factor C (RFC) transiently opens the PCNA toroid in an ATP-dependent reaction, and then allows PCNA to re-close around the double helix adjacent to the primer terminus. This leads to the formation of the "sliding clamp" (Tsurimoto et al. 1990, Mossi and Hubscher 1998). In a human telomere replication model, RFC-mediated PCNA loading increases the processivity of telomeric C-strand synthesis, but does not eliminate polymerase delta stalling on the G-rich template (Lormand et al. 2013). Interaction of RTEL1 with PCNA is needed for telomere replication and maintenance of telomere integrity (Vannier et al. 2013). |
| (summation) | [Reaction:69063] Loading of PCNA - Sliding Clamp Formation [Homo sapiens] [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere [Homo sapiens] |
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No pathways have been reviewed or authored by The binding of the primer recognition complex involves the l... (69064)
