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Details on Person At the start of the elongation phase of DNA replication, the...
| Class:Id | Summation:69033 |
|---|---|
| _displayName | At the start of the elongation phase of DNA replication, the... |
| _timestamp | 2004-09-20 13:52:52 |
| literatureReference | [LiteratureReference:68939] Initiating DNA synthesis: from recruiting to activating the MCM complex [LiteratureReference:69034] MCM proteins in DNA replication [LiteratureReference:69035] Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase [LiteratureReference:69038] Biochemical analysis of the intrinsic Mcm4-Mcm6-Mcm7 DNA helicase activity [LiteratureReference:69040] A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex [LiteratureReference:69041] The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity [LiteratureReference:69044] A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase [LiteratureReference:69045] Uninterrupted MCM2-7 function required for DNA replication fork progression [LiteratureReference:69048] Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity [LiteratureReference:69049] Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2 |
| modified | [InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00 |
| text | At the start of the elongation phase of DNA replication, the Mcm2-7 complex may re-arrange to function as the replicative helicase associated with the replication fork. In general, a replicative helicase is associated with the replication fork and unwinds DNA ahead of the polymerase. In yeast, the Mcm proteins associate with origin DNA in G1 phase and then exit the origin upon replication initiation, consistent with moving out of the origin with the replication fork. The Mcm2-7 complex is a ring-shaped hexamer. Complexes of Mcm4, Mcm6 and Mcm7 proteins from humans or S. pombe display a modest ATP-dependent helicase activity in vitro. Consistent with the hypothesis that eukaryotic Mcm complexes function as helicases, an archaeal Mcm homolog is a ring-shaped double hexamer that has a processive DNA unwinding activity. Mcm proteins may have additional functions during elongation, as uninterrupted function of all six is required for replication fork progression in budding yeast. Mcm4,6,7 helicase activity may be negatively regulated in two ways. Mcm2, Mcm4, Mcm6, and Mcm7 also form a stable complex which, however, has no helicase activity, suggesting that Mcm2 inhibits DNA unwinding by Mcm4,6,7. In addition, phosphorylation of human Mcm4,6,7 complex by CDK inhibits its helicase activity. |
| (summation) | [Reaction:69019] Mcm4,6,7 trimer forms and associates with the replication fork [Homo sapiens] |
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No pathways have been reviewed or authored by At the start of the elongation phase of DNA replication, the... (69033)
