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Details on Person The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

Class:Id	Reaction:68950
_displayName	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
_doRelease	TRUE
_timestamp	2017-04-05 15:29:21
catalystActivity	[CatalystActivity:68508] DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
input	[SimpleEntity:29604] dATP [nucleoplasm] [SimpleEntity:30185] dCTP [nucleoplasm] [SimpleEntity:29892] dGTP [nucleoplasm] [SimpleEntity:30187] dTTP [nucleoplasm] [Complex:68423] RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:8984377] Purification of a DNA polymerase-DNA primase complex from calf thymus glands
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
output	[Complex:68425] RNA primer-DNA primer:origin duplex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin [Homo sapiens] [Reaction:68914] DNA polymerase alpha:primase binds at the origin [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362008] R-HSA-68950.4
summation	[Summation:179201] At the beginning of this reaction, 1 molecule of 'dTTP', 1 m...
(hasEvent)	[Pathway:68952] DNA replication initiation [Homo sapiens]
(inferredFrom)	[Reaction:1113072] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin [Oryza sativa]
(orthologousEvent)	[Reaction:1113072] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin [Oryza sativa]
(precedingEvent)	[Reaction:69053] RFC binding displaces Pol Alpha [Homo sapiens] [Reaction:113504] Detection of damage during initiation of DNA synthesis in S-phase [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781214] Update Tracker - [Reaction:68950] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin - v61:[addLiteratureReference]
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