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Details on Person Ubiquitinated Orc1 is degraded by the proteasome

Class:Id	BlackBoxEvent:68948
_displayName	Ubiquitinated Orc1 is degraded by the proteasome
_doRelease	TRUE
_timestamp	2017-12-07 15:03:04
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
input	[EntityWithAccessionedSequence:9032195] PolyUb,p-S,T-ORC1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:68587] Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication [LiteratureReference:68612] Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9032197] Orlic-Milacic, Marija, 2017-12-07 [InstanceEdit:9032206] Orlic-Milacic, Marija, 2017-12-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitinated Orc1 is degraded by the proteasome
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:68947] Ubiquitinated Orc1 enters the cytosol [Homo sapiens] [Reaction:68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361866] R-HSA-68948.4
summation	[Summation:179281] Ubiquitinated ORC1 is degraded by the proteasome in the cyto...
(hasEvent)	[Pathway:68949] Orc1 removal from chromatin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779868] Update Tracker - [BlackBoxEvent:68948] Ubiquitinated Orc1 is degraded by the proteasome - v64:[addLiteratureReference, add_removeInput, modifyText]
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