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Details on Person MCM10 is required for human DNA replication. In S. cerevisia...

Class:IdSummation:68930
_displayNameMCM10 is required for human DNA replication. In S. cerevisia...
_timestamp2011-12-22 15:20:56
literatureReference[LiteratureReference:68931] Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
[LiteratureReference:68937] Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45
[LiteratureReference:68920] The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase
[LiteratureReference:68939] Initiating DNA synthesis: from recruiting to activating the MCM complex
[LiteratureReference:169459] A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
[LiteratureReference:169448] The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene
[LiteratureReference:169455] Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha
[LiteratureReference:169464] Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae
[LiteratureReference:169462] Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p
[LiteratureReference:169446] The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase
modified[InstanceEdit:169445] Gopinathrao, G, 2005-11-29 15:17:55
[InstanceEdit:169516] Gopinathrao, G, 2005-11-29 21:00:42
[InstanceEdit:177273] D'Eustachio, P, 2006-03-25 20:37:49
[InstanceEdit:2026113] Orlic-Milacic, M, 2011-12-22
textMCM10 is required for human DNA replication. In S. cerevisiae, Mcm10, like Mcm2-7, is required for minichromosome maintenance, but Mcm10 has no sequence homology with these other proteins (Merchant et al., 1997). Genetic studies have demonstrated that Mcm10 is required for DNA replication in S. pombe (Aves et al., 1998) and S. cerevisiae cells (Homesley et al., 2000) and immunodepletion of XlMcm10 interferes with DNA replication in Xenopus egg extracts (Wohlschlegel et al., 2002). Human Mcm10 interacts with chromatin in G1 phase and then dissociates during G2 phase. In S. cerevisiae, Mcm10 has been shown to localize to origins during G1 (Ricke and Bielinsky, 2004), and it may stabilize the association of Mcm2-7 with the pre-replicative complex (Sawyer et al., 2004). This timing of association is consistent with studies that demonstrate that, in Xenopus egg extracts, Mcm10 is required for association of Cdc45, but not Mcm2-7 with chromatin. Biochemical evidence that Mcm10 plays a direct role in the activation of the pre-replicative complex includes the requirement for SpMcm10 in the phosphorylation of the Mcm2-7 complex by DDK (Lee et al., 2004) and the fact that SpMcm10 binds and stimulates DNA polymerase alpha activity (Fien et al., 2004).
(summation)[Reaction:68919] Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 [Homo sapiens]
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