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Details on Person CDK and DDK associate with the Mcm10:pre-replicative complex

Class:Id	Reaction:68918
_displayName	CDK and DDK associate with the Mcm10:pre-replicative complex
_doRelease	TRUE
_timestamp	2017-03-06 14:20:20
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
input	[Complex:68380] CDK [nucleoplasm] [Homo sapiens] [Complex:68388] DDK [nucleoplasm] [Homo sapiens] [Complex:156564] MCM10:active pre-replicative complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:68389] Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication [LiteratureReference:68392] A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
modified	[InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49 [InstanceEdit:156566] D'Eustachio, P, 2004-11-27 18:11:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200278] D'Eustachio, P, 2007-07-16 20:47:41 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981367] Orlic-Milacic, Marija, 2017-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK and DDK associate with the Mcm10:pre-replicative complex
output	[Complex:68561] CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:68940] Cdt1 is displaced from the pre-replicative complex [Homo sapiens] [Reaction:68919] Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359395] R-HSA-68918.4
summation	[Summation:178531] At the beginning of this reaction, 1 molecule of 'Mcm10:acti...
(hasEvent)	[Pathway:68962] Activation of the pre-replicative complex [Homo sapiens]
(precedingEvent)	[Reaction:68917] Cdc45 associates with the pre-replicative complex at the origin [Homo sapiens] [Reaction:68954] Mcm2-7 is phosphorylated by DDK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792306] Update Tracker - [Reaction:68918] CDK and DDK associate with the Mcm10:pre-replicative complex - v22:[addLiteratureReference]
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No pathways have been reviewed or authored by CDK and DDK associate with the Mcm10:pre-replicative complex (68918)