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Details on Person Cdc45 associates with the pre-replicative complex at the origin

Class:Id	Reaction:68917
_displayName	Cdc45 associates with the pre-replicative complex at the origin
_doRelease	TRUE
_timestamp	2017-03-06 14:05:28
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
input	[EntityWithAccessionedSequence:68563] CDC45 [nucleoplasm] [Homo sapiens] [Complex:68561] CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:69335] Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha [LiteratureReference:69339] The human homolog of Saccharomyces cerevisiae CDC45
modified	[InstanceEdit:73900] Joshi-Tope, G, 2007-09-03 12:04:00 [InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49 [InstanceEdit:113655] Gopinathrao, G, 2004-06-14 19:10:00 [InstanceEdit:156597] D'Eustachio, P, 2004-11-29 19:29:04 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:692407] Matthews, L, 2010-05-07 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981366] Orlic-Milacic, Marija, 2017-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cdc45 associates with the pre-replicative complex at the origin
output	[Complex:68564] CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:68918] CDK and DDK associate with the Mcm10:pre-replicative complex [Homo sapiens] [Reaction:68940] Cdt1 is displaced from the pre-replicative complex [Homo sapiens] [BlackBoxEvent:8961915] CDC45 gene expression is stimulated by E2F1 [Homo sapiens] [Reaction:8961907] E2F1 binds the CDC45 gene promoter [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360344] R-HSA-68917.4
summation	[Summation:69342] Once the Mcm2-7 complex has been assembled onto the origin o...
(hasEvent)	[Pathway:68962] Activation of the pre-replicative complex [Homo sapiens]
(inferredFrom)	[Reaction:1113091] Cdc45 associates with the pre-replicative complex at the origin [Oryza sativa]
(orthologousEvent)	[Reaction:1113091] Cdc45 associates with the pre-replicative complex at the origin [Oryza sativa]
(precedingEvent)	[Reaction:68916] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788857] Update Tracker - [Reaction:68917] Cdc45 associates with the pre-replicative complex at the origin - v40:[modifyText]
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