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Details on Person DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin

Class:Id	Reaction:68916
_displayName	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
_doRelease	TRUE
_timestamp	2016-11-10 00:55:21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
input	[Complex:68567] RPA1-4 [nucleoplasm] [Homo sapiens] [Complex:68564] CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:69347] Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. [LiteratureReference:69366] Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
modified	[InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
output	[Complex:68568] CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:68917] Cdc45 associates with the pre-replicative complex at the origin [Homo sapiens] [Reaction:68918] CDK and DDK associate with the Mcm10:pre-replicative complex [Homo sapiens] [BlackBoxEvent:8961915] CDC45 gene expression is stimulated by E2F1 [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360915] R-HSA-68916.3
summation	[Summation:69369] After pre-RC assembly and Cdc45 association with the origin ...
(hasEvent)	[Pathway:68962] Activation of the pre-replicative complex [Homo sapiens]
(inferredFrom)	[Reaction:1113056] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin [Oryza sativa]
(orthologousEvent)	[Reaction:1113056] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin [Oryza sativa]
(precedingEvent)	[Reaction:68914] DNA polymerase alpha:primase binds at the origin [Homo sapiens] [Reaction:68960] DNA polymerase epsilon binds at the origin [Homo sapiens]
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No pathways have been reviewed or authored by DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (68916)