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Details on Person The deubiquitinase A20 is a negative feedback regulator of i...

Class:Id	Summation:688984
_displayName	The deubiquitinase A20 is a negative feedback regulator of i...
_timestamp	2011-04-08 16:02:53
created	[InstanceEdit:688983] Jupe, S, 2010-05-07
literatureReference	[LiteratureReference:688977] Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements [LiteratureReference:688990] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo [LiteratureReference:1247975] The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals
modified	[InstanceEdit:689007] Jupe, S, 2010-05-07 [InstanceEdit:1247993] Jupe, S, 2011-04-08
text	The deubiquitinase A20 is a negative feedback regulator of inflammatory responses, induced by NFkappaB activation (Krikos et al. 1992) and NOD stimulation (Masumoto et al. 2006). A20 can deubiquitinate RIP2 and restricts NOD2 induced signals (Hitosumatsu et al. 2008).
(summation)	[Reaction:688136] TNFAIP3 (A20) deubiquitinates RIP2 [Homo sapiens]
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