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Details on Person Ubiquitinated geminin is degraded by the proteasome

Class:Id	BlackBoxEvent:68825
_displayName	Ubiquitinated geminin is degraded by the proteasome
_doRelease	TRUE
_timestamp	2021-11-17 22:13:38
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
edited	[InstanceEdit:9758524] Orlic-Milacic, Marija, 2021-11-17
input	[EntityWithAccessionedSequence:68585] PolyUb-GMNN [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:68718] Geminin, an inhibitor of DNA replication, is degraded during mitosis. [LiteratureReference:9757412] The APC/C inhibitor, Emi1, is essential for prevention of rereplication
modified	[InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:143525] Schmidt, EE, 2004-11-12 05:53:46 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:508491] Matthews, L, 2010-02-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9757418] Orlic-Milacic, Marija, 2021-10-30 [InstanceEdit:9757421] Orlic-Milacic, Marija, 2021-10-30 [InstanceEdit:9758524] Orlic-Milacic, Marija, 2021-11-17 [InstanceEdit:9758525] Orlic-Milacic, Marija, 2021-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitinated geminin is degraded by the proteasome
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9758287] Kusic-Tisma, Jelena, 2021-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358289] R-HSA-68825.4
summation	[Summation:179279] APC/C-dependent degradation of geminin (GMNN) was first demo...
(hasEvent)	[Pathway:68867] Assembly of the pre-replicative complex [Homo sapiens] [Pathway:9734667] (NEW) Assembly of the ORC complex at the origin of replication [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775435] Update Tracker - [BlackBoxEvent:68825] Ubiquitinated geminin is degraded by the proteasome - v79:[add_removeCatalystActivity, add_removeLiteratureReference, add_removeOutput, modifyText]
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