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Details on Person TNFAIP3 (A20) deubiquitinates RIP2

Class:Id	Reaction:688136
_displayName	TNFAIP3 (A20) deubiquitinates RIP2
_doRelease	TRUE
_timestamp	2016-05-16 07:30:57
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
catalystActivity	[CatalystActivity:688991] K63-linked deubiquitinase activity of TNFAIP3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643552] Lys63-specific deubiquitinase activity of TNFAIP3 [cytosol] Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:688134] Jupe, S, 2010-05-06
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[Complex:706480] PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:688135] A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
modified	[InstanceEdit:688983] Jupe, S, 2010-05-07 [InstanceEdit:708309] Jupe, S, 2010-05-10 [InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1361856] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:5690836] Jupe, Steve, 2015-04-30 [InstanceEdit:6782109] Jupe, Steve, 2015-06-04 [InstanceEdit:8871338] Jupe, Steve, 2016-05-16 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TNFAIP3 (A20) deubiquitinates RIP2
output	[Complex:688994] PAMP:NOD oligomer:RIP2:NEMO [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
precedingEvent	[Reaction:688137] RIP2 is K63 polyubiquitinated [Homo sapiens] [Reaction:168405] Activated NOD oligomer recruites RIP2 (RICK) [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357620] R-HSA-688136.5
summation	[Summation:688984] The deubiquitinase A20 is a negative feedback regulator of i...
(hasEvent)	[Pathway:168638] NOD1/2 Signaling Pathway [Homo sapiens] [Pathway:5689896] Ovarian tumor domain proteases [Homo sapiens]
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