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Query author contributions in Reactome

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Details on Person CDC6 association with ORC(1-6) at replication origins

Class:IdReaction:68688
_displayNameCDC6 association with ORC(1-6) at replication origins
_doReleaseTRUE
_timestamp2021-11-10 11:42:42
authored[InstanceEdit:176978] Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
edited[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
input[EntityWithAccessionedSequence:68542] CDC6 [nucleoplasm] [Homo sapiens]
[Complex:9749111] ORC(1-6):origin of replication [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:176943] Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin
[LiteratureReference:9749209] Structure of the active form of human origin recognition complex and its ATPase motor module
[LiteratureReference:169444] MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
[LiteratureReference:9749223] MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors
[LiteratureReference:9749250] Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
[LiteratureReference:9749236] Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy
[LiteratureReference:9749237] Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6
[LiteratureReference:9749238] Conformational control and DNA-binding mechanism of the metazoan origin recognition complex
[LiteratureReference:9749246] Crystal structure of the eukaryotic origin recognition complex
modified[InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:176962] Gopinathrao, G, 2006-03-17 19:09:52
[InstanceEdit:176979] Gopinathrao, G, 2006-03-17 21:01:39
[InstanceEdit:2671733] D'Eustachio, P, 2012-11-23
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9757625] Orlic-Milacic, Marija, 2021-11-03
[InstanceEdit:9758289] Orlic-Milacic, Marija, 2021-11-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCDC6 association with ORC(1-6) at replication origins
output[Complex:9749216] ORC(1-6):CDC6:origin of replication [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9749210] Positive regulation by 'CDC6:MCM8 [nucleoplasm]'
releaseDate2004-07-06
reviewed[InstanceEdit:9758287] Kusic-Tisma, Jelena, 2021-11-05
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9757641] Orlic-Milacic, Marija, 2021-11-03
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358996] R-HSA-68688.4
summation[Summation:9749234] CDC6 binds to the origin of replication complex (ORC) by dir...
(hasEvent)[Pathway:68689] CDC6 association with the ORC:origin complex [Homo sapiens]
(inferredFrom)[Reaction:1113066] CDC6 association with ORC:origin complexes mediated by MCM8 [Oryza sativa]
(orthologousEvent)[Reaction:1113066] CDC6 association with ORC:origin complexes mediated by MCM8 [Oryza sativa]
(updatedInstance)[_UpdateTracker:9775431] Update Tracker - [Reaction:68688] CDC6 association with ORC(1-6) at replication origins - v79:[addRegulator, add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]
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