Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RB1 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:68642
_displayName	RB1 [nucleoplasm]
_timestamp	2013-06-12 15:47:13
compartment	[Compartment:7660] nucleoplasm
endCoordinate	928
modified	[InstanceEdit:73680] Gillespie, ME, 0000-00-00 00:00:00 [InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00 [InstanceEdit:113706] Matthews, L, 2004-06-19 02:00:00 [InstanceEdit:141390] Matthews, L, 2004-09-17 15:02:31 [InstanceEdit:2172667] Orlic-Milacic, M, 2012-03-29 [InstanceEdit:3702075] Jupe, S, 2013-06-12
name	RB1 Retinoblastoma Protein 1 Retinoblastoma-associated protein pRb RBP1 Rb-binding protein 1
referenceEntity	[ReferenceGeneProduct:62886] UniProt:P06400 RB1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:369891] R-HSA-68642.2
startCoordinate	2
(activeUnit)	[PositiveRegulation:4722147] Positive regulation by 'Condensin II:RB1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9794241] Positive gene expression regulation by 'RB1:TFAP2A homodimer:CDH1 gene [nucleoplasm]'
(hasComponent)	[Complex:68644] RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] [Homo sapiens] [Complex:68647] Rb:E2F1:DP1 [nucleoplasm] [Homo sapiens] [Complex:68650] Rb:E2F2:DP-1 [nucleoplasm] [Homo sapiens] [Complex:68656] Rb:E2F3:DP-1 [nucleoplasm] [Homo sapiens] [Complex:68665] Rb:E2F4:DP-1 [nucleoplasm] [Homo sapiens] [Complex:68670] Rb:E2F5:DP-1 [nucleoplasm] [Homo sapiens] [Complex:113646] RB1:RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm] [Homo sapiens] [Complex:182508] DP-1:E2F:Rb complex [nucleoplasm] [Homo sapiens] [Complex:188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] [Homo sapiens] [Complex:2172665] Condensin II:RB1 [nucleoplasm] [Homo sapiens] List all 17 refering instances
(inferredFrom)	[DefinedSet:1113308] Homologues of Retinoblastoma Protein 1 [nucleoplasm] [Oryza sativa] [EntityWithAccessionedSequence:1114000] Q2R374 [nucleoplasm] [Oryza sativa] [EntityWithAccessionedSequence:1114056] Q84QM3 [nucleoplasm] [Oryza sativa]
(input)	[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:2172666] RB1 binds condensin II [Homo sapiens] [Reaction:8878379] PRDM2 binds RB1 [Homo sapiens] [Reaction:8985460] RUNX2 binds RB1 [Homo sapiens] [Reaction:8985474] Runx2 binds RB1 [Homo sapiens] [Reaction:9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Homo sapiens] [Reaction:9768288] RB1 and TFAP2A bind CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9851127] NPM1-ALK-dependent repression of pRB phosphorylation [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9659798] loss_of_function and partial_loss_of_function of RB1 mutants (E2F binding) [nucleoplasm] [EntityFunctionalStatus:9687399] loss_of_function of RB1 T738_R775del [nucleoplasm]
(output)	[BlackBoxEvent:188191] APC/C:Cdh1-mediated degradation of Skp2 [Homo sapiens] [BlackBoxEvent:8954733] Upregulated expression of RB1 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
(regulator)	[PositiveRegulation:4648284] Positive regulation by 'RB1 [nucleoplasm]' [NegativeRegulation:8979098] Negative regulation by 'RB1 [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9872392] Update Tracker - [EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] - v41:[addName, modifyEndCoordinate, modifyStartCoordinate] [_UpdateTracker:9888064] Update Tracker - [EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] - v46:[addName]
[Change default viewing format]

No pathways have been reviewed or authored by RB1 [nucleoplasm] (68642)