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Details on Person Formation of ORC(2-5) complex
Class:Id Reaction:68610
_displayName Formation of ORC(2-5) complex
_doRelease TRUE
_timestamp 2021-11-10 11:40:25
authored [InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
edited [InstanceEdit:9750784] Orlic-Milacic, Marija, 2021-08-16
input [EntityWithAccessionedSequence:68519] ORC4 [nucleoplasm] [Homo sapiens] [Complex:9735402] ORC2:ORC3:ORC5 [nucleoplasm] [Homo sapiens]
literatureReference [LiteratureReference:9735369] A structural role for ATP in the formation and stability of the human origin recognition complex [LiteratureReference:9735378] ATP-dependent assembly of the human origin recognition complex [LiteratureReference:9735412] The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle [LiteratureReference:9735417] Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex [LiteratureReference:9735409] Interactions and subcellular distribution of DNA replication initiation proteins in eukaryotic cells [LiteratureReference:9734659] Assembly of the human origin recognition complex occurs through independent nuclear localization of its components [LiteratureReference:9749153] Structural insight into the assembly and conformational activation of human origin recognition complex [LiteratureReference:9749160] The dynamic nature of the human origin recognition complex revealed through five cryoEM structures
modified [InstanceEdit:111625] Joshi-Tope, G, 2004-03-03 09:38:49 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9750798] Orlic-Milacic, Marija, 2021-08-16 [InstanceEdit:9750805] Orlic-Milacic, Marija, 2021-08-16 [InstanceEdit:9750923] Orlic-Milacic, Marija, 2021-08-17 [InstanceEdit:9757726] Orlic-Milacic, Marija, 2021-11-04 [InstanceEdit:9758288] Orlic-Milacic, Marija, 2021-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Formation of ORC(2-5) complex
output [Complex:9735403] ORC(2-5) [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy [PositiveRegulation:9757724] Positive regulation by 'ATP [nucleoplasm]'
releaseDate 2004-07-06
reviewed [InstanceEdit:9758287] Kusic-Tisma, Jelena, 2021-11-05
reviewStatus [ReviewStatus:9821382] five stars
revised [InstanceEdit:9750795] Kusic-Tisma, Jelena, 2021-06-24 [InstanceEdit:9757725] Orlic-Milacic, Marija, 2021-11-04
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:358526] R-HSA-68610.5
summation [Summation:9735393] ORC4 forms a complex with the heterotrimer of ORC2, ORC3 and...
(hasEvent) [Pathway:68616] Assembly of the ORC complex at the origin of replication [Homo sapiens] [Pathway:9734667] (NEW) Assembly of the ORC complex at the origin of replication [Homo sapiens]
(inferredFrom) [Reaction:1113089] Orc4 associates with Orc5:Orc3:Orc2:origin complexes [Oryza sativa]
(orthologousEvent) [Reaction:1113089] Orc4 associates with Orc5:Orc3:Orc2:origin complexes [Oryza sativa]
(precedingEvent) [Reaction:68611] Formation of ORC(1-5) complex [Homo sapiens]
(updatedInstance) [_UpdateTracker:9775386] Update Tracker - [Reaction:68610] Formation of ORC(2-5) complex - v79:[addRegulator] [_UpdateTracker:9775618] Update Tracker - [Reaction:68610] Formation of ORC(2-5) complex - v78:[add_removeInput, add_removeLiteratureReference, add_removeOutput, add_removeSummation]
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