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Details on Person UniProt:Q99741 CDC6
| Class:Id | ReferenceGeneProduct:68541 |
|---|---|
| _chainChangeLog | chain:1-560 added on Sat February 7 2015 |
| _displayName | UniProt:Q99741 CDC6 |
| _timestamp | 2024-11-03 19:55:35 |
| chain | chain:1-560 |
| checksum | 3ED7DE4AF80CB017 |
| comment | FUNCTION Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.SUBUNIT Interacts with PCNA, ORC1, cyclin-CDK (PubMed:9566895). Interacts with HUWE1 (PubMed:17567951). Interacts with ANKRD17 (PubMed:23711367). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with TTC4 (PubMed:18320024). Interacts (via Cy motif) with CCNF; the interaction takes place during G2 and M phase (PubMed:26818844). Interacts with CDH1 (PubMed:26818844).INTERACTION The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).PTM Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CDC6/cdc18 family. |
| description | recommendedName: Cell division control protein 6 homolog alternativeName: CDC6-related protein alternativeName: Cdc18-related protein shortName: HsCdc18 alternativeName: p62(cdc6) shortName: HsCDC6 |
| geneName | CDC6 CDC18L |
| identifier | Q99741 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell cycle Cell division Cytoplasm Disease variant DNA replication Dwarfism Mitosis Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDC6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961624] ENSEMBL:ENSG00000094804 CDC6 [Homo sapiens] |
| secondaryIdentifier | CDC6_HUMAN Q8TB30 |
| sequenceLength | 560 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68542] CDC6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68583] p-CDC6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:113566] CDC6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5661317] p-CDC6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9988446] p-S54,S74,S106-CDC6 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2869452] phosphorylated residue at unknown position [ModifiedResidue:9988445] O-phospho-L-serine at 106 [ModifiedResidue:9988454] O-phospho-L-serine at 54 [ModifiedResidue:9988455] O-phospho-L-serine at 74 |
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No pathways have been reviewed or authored by UniProt:Q99741 CDC6 (68541)
