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Details on Person UniProt:Q9H211 CDT1
| Class:Id | ReferenceGeneProduct:68535 |
|---|---|
| _chainChangeLog | chain:1-546 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H211 CDT1 |
| _timestamp | 2025-08-15 21:59:27 |
| chain | chain:1-546 |
| checksum | 8179D0330C135FB7 |
| comment | FUNCTION Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).SUBUNIT Interacts with GMNN; the interaction inhibits binding of the MCM complex to origins of replication (PubMed:11125146, PubMed:14672932, PubMed:14993212, PubMed:15257290). Interacts with MCM6 (By similarity). Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with PCNA (PubMed:16861906). Interacts with LRWD1 during G1 phase and during mitosis (PubMed:22645314). Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (PubMed:22581055). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with KAT7 (PubMed:18832067). Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (PubMed:26842564).INTERACTION Transiently localizes to kinetochores during prometaphase and metaphase.DEVELOPMENTAL STAGE Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.INDUCTION Induced by E2F transcription factors (PubMed:14990995).DOMAIN The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.PTM Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase (PubMed:14993212, PubMed:16861906, PubMed:16949367, PubMed:17085480). Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation (PubMed:16861906, PubMed:17085480). Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation (PubMed:16861906, PubMed:17085480). Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination (PubMed:15257290). Deubiquitinated by USP37 (PubMed:27296872). Ubiquitinated and degraded by the SCF(FBXO31) complex during the G2 phase to prevent re-replication (PubMed:24828503).PTM Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Cdt1 family. |
| description | recommendedName: DNA replication factor Cdt1 alternativeName: Double parked homolog shortName: DUP |
| geneName | CDT1 |
| identifier | Q9H211 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Centromere Chromosome Disease variant DNA replication Dwarfism Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CDT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961941] ENSEMBL:ENSG00000167513 CDT1 [Homo sapiens] |
| secondaryIdentifier | CDT1_HUMAN Q86XX9 Q96CJ5 Q96GK5 Q96H67 Q96HE6 Q9BWM0 |
| sequenceLength | 546 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68536] CDT1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:113788] CDT1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H211 CDT1 (68535)
