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Details on Person UniProt:Q9UBU7 DBF4
| Class:Id | ReferenceGeneProduct:68386 |
|---|---|
| _chainChangeLog | chain:1-674 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UBU7 DBF4 |
| _timestamp | 2024-11-03 19:45:21 |
| chain | chain:1-674 |
| checksum | 353FEB7E85507E5C |
| comment | FUNCTION Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.SUBUNIT Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176).INTERACTION Highly expressed in testis and thymus. Expressed also in most cancer cells lines.INDUCTION Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase.PTM Phosphorylation increases its interaction with PSIP1. |
| description | recommendedName: Protein DBF4 homolog A alternativeName: Activator of S phase kinase alternativeName: Chiffon homolog A alternativeName: DBF4-type zinc finger-containing protein 1 |
| geneName | DBF4 ASK DBF4A ZDBF1 |
| identifier | Q9UBU7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle DNA replication Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DBF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994757] ENSEMBL:ENSG00000006634 DBF4 [Homo sapiens] |
| secondaryIdentifier | DBF4A_HUMAN A4D1D8 A8K954 O75226 Q75MS6 Q75N01 Q9Y2M6 |
| sequenceLength | 674 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:226447] UniProt:Q9UBU7-2 DBF4 [Homo sapiens] [ReferenceIsoform:415314] UniProt:Q9UBU7-1 DBF4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68387] DBF4 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UBU7 DBF4 (68386)
