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Details on Person UniProt:P30281 CCND3
| Class:Id | ReferenceGeneProduct:68332 |
|---|---|
| _chainChangeLog | chain:1-292 added on Fri February 6 2015 |
| _displayName | UniProt:P30281 CCND3 |
| _timestamp | 2026-02-20 21:57:26 |
| chain | chain:1-292 |
| checksum | 16E7B1604FEB0029 |
| comment | FUNCTION Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120).SUBUNIT Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (PubMed:19237555, PubMed:8114739, PubMed:9106657). Interacts with isoform p58 of CDK11 (CDK11A or CDK11B) to form a serine/threonine kinase holoenzyme complex (PubMed:12082095). The cyclin subunit imparts substrate specificity to the complex (PubMed:8114739). Interacts with ATF5 (PubMed:15358120). Interacts with EIF3K (PubMed:15327989). Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (PubMed:16782892). Can form similar complexes with either CDKN1A or CDKN2A (PubMed:16782892, PubMed:9106657).INTERACTION Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.PTM Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-283 phosphorylation (PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex represents the major regulator of CCND3 stability during the G1/S transition (PubMed:33854235, PubMed:33854239). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (PubMed:22020328).SIMILARITY Belongs to the cyclin family. Cyclin D subfamily. |
| description | recommendedName: fullName evidence="20"G1/S-specific cyclin-D3 |
| geneName | CCND3 |
| identifier | P30281 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Cyclin Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CCND3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004583] ENSEMBL:ENSG00000112576 CCND3 [Homo sapiens] |
| secondaryIdentifier | CCND3_HUMAN B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49 |
| sequenceLength | 292 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972315] UniProt:P30281-1 CCND3 [Homo sapiens] [ReferenceIsoform:8972316] UniProt:P30281-2 CCND3 [Homo sapiens] [ReferenceIsoform:8972317] UniProt:P30281-3 CCND3 [Homo sapiens] [ReferenceIsoform:8972318] UniProt:P30281-4 CCND3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68333] CCND3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:113835] CCND3 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P30281 CCND3 (68332)
