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Details on Person UniProt:O60481 ZIC3
| Class:Id | ReferenceGeneProduct:68160 |
|---|---|
| _chainChangeLog | chain:1-467 added on Fri February 6 2015 |
| _displayName | UniProt:O60481 ZIC3 |
| _timestamp | 2024-11-03 20:22:24 |
| chain | chain:1-467 |
| checksum | 3150CF13C0679568 |
| comment | FUNCTION Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.SUBUNIT Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity). Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity.SUBCELLULAR LOCATION Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.ALTERNATIVE PRODUCTS The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GLI C2H2-type zinc-finger protein family. |
| description | recommendedName: Zinc finger protein ZIC 3 alternativeName: Zinc finger protein 203 alternativeName: Zinc finger protein of the cerebellum 3 |
| geneName | ZIC3 ZNF203 |
| identifier | O60481 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Cytoplasm Developmental protein Differentiation Disease variant DNA-binding Heterotaxy Isopeptide bond Metal-binding Neurogenesis Nucleus Proteomics identification Reference proteome Repeat Transcription Transcription regulation Triplet repeat expansion Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZIC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888895] ENSEMBL:ENSG00000156925 ZIC3 [Homo sapiens] |
| secondaryIdentifier | ZIC3_HUMAN B2CNW4 Q14DE5 Q5JY75 |
| sequenceLength | 467 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966845] UniProt:O60481-1 ZIC3 [Homo sapiens] [ReferenceIsoform:8966846] UniProt:O60481-2 ZIC3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:480800] ZIC3 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60481 ZIC3 (68160)
