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Details on Person Corneodesmosomes are a modified form of desmosome that diffe...
| Class:Id | Summation:6814762 |
|---|---|
| _displayName | Corneodesmosomes are a modified form of desmosome that diffe... |
| _timestamp | 2015-11-27 16:52:32 |
| created | [InstanceEdit:6814761] Jupe, Steve, 2015-11-27 |
| literatureReference | [LiteratureReference:6814726] Desmosomes, corneosomes and desquamation. An ultrastructural study of adult pig epidermis [LiteratureReference:6814717] Corneodesmosomes and corneodesmosin: from the stratum corneum cohesion to the pathophysiology of genodermatoses [LiteratureReference:6814748] Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes [LiteratureReference:6814348] Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope [LiteratureReference:6814749] Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process |
| text | Corneodesmosomes are a modified form of desmosome that differs ultrastructurally (Chapman & Walsh 1990). When desmosomes are transformed into corneodesmosomes between the stratum granulosum and the stratum corneum, the desmoglea loses its trilamellar structure and becomes homogeneously electron dense. On the cytoplasmic side, the attachment plaque (desmosomal plaque) becomes incorporated into the cornified cell envelope. Keratin filaments are connected to the attachment plaque in desmosomes; this association is no longer visible in corneodesmosomes. Like desmosomes, desmoglein and desmocollin constitute the extracellular parts of corneodesmosomes (Simon et al. 1997), but there is an additional unique extracellular component known as corneodesmosin. Cleavage of desmoglein, desmocollin and corneodesmosin is a key step in desquamation Corneodesmosin (CDSN) is a 52- to 56-kDa glycoprotein produced by keratinocytes that is incorporated into the desmoglea of desmosomes shortly before their transformation into corneodesmosomes during cornification (Serre et al. 1991). It is stored and secreted by Lamellar bodies. After secretion corneodesmosin localizes to the extracellular structures of corneodesmosomes and covalently cross-links to the cornified cell envelope. This step coincides with the morphological transformation of desmosomes into corneodesmosomes. In vitro studies suggest that corneodesmosin mediates homophilic binding to counterparts on adjacent corneocytes (Ishida-Yamamoto & Kishibe 2011). |
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