Query author contributions in Reactome
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Details on Person PERP (p53 effector related to PMP-22) is a p53/p63 target ge...
| Class:Id | Summation:6814740 |
|---|---|
| _displayName | PERP (p53 effector related to PMP-22) is a p53/p63 target ge... |
| _timestamp | 2016-01-13 09:45:50 |
| created | [InstanceEdit:6814704] Jupe, Steve, 2015-11-27 |
| literatureReference | [LiteratureReference:6800838] PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family [LiteratureReference:6814722] p63 and p73 are required for p53-dependent apoptosis in response to DNA damage [LiteratureReference:6800842] Perp is a p63-regulated gene essential for epithelial integrity |
| modified | [InstanceEdit:8852147] Jupe, Steve, 2016-01-13 |
| text | PERP (p53 effector related to PMP-22) is a p53/p63 target gene involved in DNA damage-induced apoptosis (Flores et al. 2002). It is a tetraspan membrane protein,distantly related to members of the claudin/PMP-22/EMP family of four-pass membrane proteins (Attardi et al. 2000). It has an epithelial-specific expression pattern during embryogenesis and localizes to desmosomes. Perp -/- knockout mice exhibit numerous desmosomal structural defects, suggesting a role for Perp in promoting the stable assembly of desmosomal adhesive complexes (Ihrie et al. 2005). |
| (summation) | [Reaction:6814695] PERP binds desmosomes [Homo sapiens] |
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No pathways have been reviewed or authored by PERP (p53 effector related to PMP-22) is a p53/p63 target ge... (6814740)
