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Details on Person NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN

Class:Id	Reaction:6814683
_displayName	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
_doRelease	TRUE
_timestamp	2016-02-19 18:19:42
authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
catalystActivity	[CatalystActivity:6814679] ATP hydrolysis activity of STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6814685] Rothfels, Karen, 2015-11-27
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
input	[Complex:6814660] STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5688473] Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles [LiteratureReference:5688485] An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion [LiteratureReference:5688502] Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion [LiteratureReference:5688488] Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles [LiteratureReference:5688492] Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor [LiteratureReference:5688493] NSF N-terminal domain crystal structure: models of NSF function [LiteratureReference:5688498] Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) [LiteratureReference:5688193] Membrane fusion: grappling with SNARE and SM proteins
modified	[InstanceEdit:8851190] Rothfels, Karen, 2016-01-05 [InstanceEdit:8856721] Rothfels, Karen, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
output	[EntityWithAccessionedSequence:6811002] STX16 [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:6811007] STX6 [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:6811021] VAMP4 [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:6813927] VTI1A [trans-Golgi network membrane] [Homo sapiens] [Complex:2193131] NSF hexamer [cytosol] [Homo sapiens] [CandidateSet:5694313] SNAPs [cytosol] [Homo sapiens] [CandidateSet:5694313] SNAPs [cytosol] [Homo sapiens] [CandidateSet:5694313] SNAPs [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN [Homo sapiens] [BlackBoxEvent:6814682] Fusion of early-endosome derived vesicles at the TGN [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860974] R-HSA-6814683.2
summation	[Summation:5694378] NSF-dependent hydrolysis of ATP is required to disassociate ...
(hasEvent)	[Pathway:6811440] Retrograde transport at the Trans-Golgi-Network [Homo sapiens]
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