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Details on Person Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins

Class:Id	Reaction:6814674
_displayName	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins
_doRelease	TRUE
_timestamp	2016-02-19 18:19:42
authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6814677] Rothfels, Karen, 2015-11-27
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
input	[Complex:6814662] RAB9:GTP:p-RABEPK:VAMP3:late endosome-to-TGN cargo [transport vesicle] [Homo sapiens] [Complex:6811301] GARP complex [trans-Golgi network membrane] [Homo sapiens] [Complex:6814651] STX10:STX16:VTI1A [trans-Golgi network membrane] [Homo sapiens] [Complex:6814043] GCC2 dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6813977] Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi [LiteratureReference:6814020] The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure [LiteratureReference:6813928] A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling [LiteratureReference:6811214] Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network [LiteratureReference:6811192] A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [LiteratureReference:6814579] Rab9 functions in transport between late endosomes and the trans Golgi network [LiteratureReference:6814845] Membrane tethering
modified	[InstanceEdit:8847566] Rothfels, Karen, 2015-11-30 [InstanceEdit:8851210] Rothfels, Karen, 2016-01-05 [InstanceEdit:8856699] Rothfels, Karen, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins
output	[Complex:6814664] RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] [Homo sapiens]
precedingEvent	[Reaction:6814670] ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation [Homo sapiens] [Reaction:6814675] RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860976] R-HSA-6814674.2
summation	[Summation:8847553] RAB9 positive vesicles from the late endosomes are tethered ...
(hasEvent)	[Pathway:6811440] Retrograde transport at the Trans-Golgi-Network [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6814671] Fusion of late-endosome derived vesicles at the TGN [Homo sapiens]
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