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Details on Person Retrograde traffic of mannose-6-phosphate receptors (M6PRs) ...
| Class:Id | Summation:6814605 |
|---|---|
| _displayName | Retrograde traffic of mannose-6-phosphate receptors (M6PRs) ... |
| _timestamp | 2016-01-05 20:43:28 |
| created | [InstanceEdit:6814606] Rothfels, Karen, 2015-11-27 |
| modified | [InstanceEdit:8847894] Rothfels, Karen, 2015-12-02 [InstanceEdit:8851205] Rothfels, Karen, 2016-01-05 |
| text | Retrograde traffic of mannose-6-phosphate receptors (M6PRs) from the late endosome depends on RAB9 (Lombardi et al, 1993; Riederer et al, 1994; Barbero et al, 2002; reviewed in Pfeffer, 2011). Cargo recognition at the late endosome is mediated by the RAB9-interacting protein PLIN3/TIP47, which concentrates retrograde cargo into VAMP3 RAB9 positive vesicles (Diaz et al, 1998; Carroll et al, 2001; Reddy et al, 2006; Ganley et al, 2008). RABEPK is another RAB9:GTP interacting protein that is required for retrograde transport of M6PR to the TGN (Diaz et al, 1997). At the trans-Golgi network, RAB9 and PILN3 interact with the atypical RHO GTPase related protein RHOBTB3. This interaction is required for the TGN-localization of RAB9 M6PR positive vesicles. Interaction of RAB9 with the C-terminal domain of RHOBTB3 relieves an inhibitory intramolecular interaction in RHOBTB3, allowing the N-terminal domain to achieve maximal ATP hydrolysis, which is thought to promote the release of PLIN3/TIP47 as a precursor to vesicle fusion at the TGN (Espinosa et al, 2009) |
| (summation) | [Reaction:6814675] RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN [Homo sapiens] |
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