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Details on Person Integrator complex processes the 3' end of snRNA

Class:IdBlackBoxEvent:6814555
_displayNameIntegrator complex processes the 3' end of snRNA
_doReleaseTRUE
_timestamp2016-11-19 11:46:55
authored[InstanceEdit:6814548] May, Bruce, 2015-11-21
catalystActivity[CatalystActivity:6814550] RNA endonuclease activity of RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6814552] May, Bruce, 2015-11-27
edited[InstanceEdit:6814548] May, Bruce, 2015-11-21
input[Complex:6814860] RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:6814890] Human snRNA genes use polyadenylation factors to promote efficient transcription termination
[LiteratureReference:6814900] The Integrator complex controls the termination of transcription at diverse classes of gene targets
[LiteratureReference:6814921] snRNA 3' end formation requires heterodimeric association of integrator subunits
[LiteratureReference:6807461] Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
[LiteratureReference:6814918] CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing
modified[InstanceEdit:6814922] May, Bruce, 2015-11-29
[InstanceEdit:6814947] May, Bruce, 2015-11-30
[InstanceEdit:8858398] May, Bruce, 2016-02-19
[InstanceEdit:8949111] May, Bruce, 2016-11-19
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIntegrator complex processes the 3' end of snRNA
output[Complex:6814530] RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] [Homo sapiens]
[Complex:6814903] CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[Requirement:8949106] Requirement by 'SSU72 [nucleoplasm]'
[Requirement:8949107] Requirement by 'PCF11 [nucleoplasm]'
regulationReference[RegulationReference:9641523] Requirement by 'SSU72 [nucleoplasm]' Human snRNA genes use polyadenylation factors to promote efficient transcription termination
[RegulationReference:9642813] Requirement by 'PCF11 [nucleoplasm]' Human snRNA genes use polyadenylation factors to promote efficient transcription termination
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8858395] Hernandez, Nouria, 2016-02-19
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861405] R-HSA-6814555.5
summation[Summation:6814895] Transcription of the pre-snRNA extends through a conserved r...
(hasEvent)[Pathway:6807505] RNA polymerase II transcribes snRNA genes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:6814554] Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781851] Update Tracker - [BlackBoxEvent:6814555] Integrator complex processes the 3' end of snRNA - v60:[addRegulator]
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No pathways have been reviewed or authored by Integrator complex processes the 3' end of snRNA (6814555)
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