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Details on Person PXLP-K333-GADL1 decarboxylates CSA to HTAU

Class:IdReaction:6814165
_displayNamePXLP-K333-GADL1 decarboxylates CSA to HTAU
_doReleaseTRUE
_timestamp2025-02-25 22:17:22
authored[InstanceEdit:6814166] Jassal, Bijay, 2015-11-25
catalystActivity[CatalystActivity:6787750] carboxy-lyase activity of PXLP-K333-GADL1 dimer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:6814166] Jassal, Bijay, 2015-11-25
crossReference[DatabaseIdentifier:9925799] RHEA:16878
edited[InstanceEdit:6814166] Jassal, Bijay, 2015-11-25
input[SimpleEntity:6787748] CSA [cytosol]
[SimpleEntity:70106] H+ [cytosol]
internalReviewed[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimericFALSE
literatureReference[LiteratureReference:6787752] Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis
[LiteratureReference:6787749] Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases
[LiteratureReference:9644690] Structure of the mouse acidic amino acid decarboxylase GADL1
modified[InstanceEdit:6814168] Jassal, Bijay, 2015-11-25
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9015697] Jassal, Bijay, 2017-08-11
[InstanceEdit:9603979] Jassal, Bijay, 2018-03-29
[InstanceEdit:9644697] D'Eustachio, Peter, 2019-04-17
[InstanceEdit:9644734] D'Eustachio, Peter, 2019-04-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29
[InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06
[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
namePXLP-K333-GADL1 decarboxylates CSA to HTAU
3-sulfino-L-alanine + H(+) => CO2 + hypotaurine
output[SimpleEntity:1655445] HTAU [cytosol]
[SimpleEntity:113528] CO2 [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2018-06-12
reviewed[InstanceEdit:9603980] Haavik, Jan, 2018-03-29
[InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8927690] R-HSA-6814165.4
structureModified[InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29
summation[Summation:6814167] Acidic amino acid decarboxylase GADL1 (GADL1) can decarboxyl...
(hasEvent)[Pathway:1614558] Degradation of cysteine and homocysteine [Homo sapiens]
(precedingEvent)[Reaction:1655453] FMO1:FAD oxidizes HTAU to TAU [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777728] Update Tracker - [Reaction:6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU - v69:[addLiteratureReference, modifyText]
[_UpdateTracker:9939627] Update Tracker - [Reaction:6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU - v92:[removeInput]
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