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Details on Person GDE1 (glycerophosphodiester phosphodiesterase 1) catalyzes t...
| Class:Id | Summation:6813738 |
|---|---|
| _displayName | GDE1 (glycerophosphodiester phosphodiesterase 1) catalyzes t... |
| _timestamp | 2015-11-30 15:42:05 |
| created | [InstanceEdit:6813739] D'Eustachio, Peter, 2015-11-23 |
| modified | [InstanceEdit:8847429] D'Eustachio, Peter, 2015-11-30 |
| text | GDE1 (glycerophosphodiester phosphodiesterase 1) catalyzes the hydrolysis of GroPIns (1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol; glycerophosphoinositol) to G3P (glycerol-3-phosphate) and Ins (inositol). Experimental studies of the homologous rat enzyme have shown it to be associated with cellular membranes, to have a strong preference for glycerophosphoinositol over glycerophosphocholine as a substrate, and to be stimulated by G protein agonists, suggesting a possible role for GDE1 in signaling by G protein-coupled receptors (Zheng et al. 2000, 2003). Modeling studies with the human protein have been interpreted to suggest localization specifically to the plasma membrane (Bachmann et al. 2006). |
| (summation) | [Reaction:6813740] GDE1 hydrolyzes GroPIns [Homo sapiens] |
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