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Details on Person NCEH1 hydrolyzes cholesterol esters

Class:Id	Reaction:6813720
_displayName	NCEH1 hydrolyzes cholesterol esters
_doRelease	TRUE
_timestamp	2016-06-16 10:49:15
authored	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
catalystActivity	[CatalystActivity:6813682] sterol ester esterase activity of NCEH1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:13977] lipid droplet [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
edited	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
input	[SimpleEntity:163579] CHEST [lipid droplet] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6813679] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence [LiteratureReference:6813687] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages [LiteratureReference:6813673] Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages [LiteratureReference:6813674] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages
modified	[InstanceEdit:8847446] D'Eustachio, Peter, 2015-11-30 [InstanceEdit:8876733] Jassal, Bijay, 2016-06-16 [InstanceEdit:8876736] Jassal, Bijay, 2016-06-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NCEH1 hydrolyzes cholesterol esters
output	[SimpleEntity:216762] CHOL [transport vesicle membrane] [SimpleEntity:8876730] LCFA(-) [cytosol]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8847445] Jassal, Bijay, 2015-11-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860983] R-HSA-6813720.3
summation	[Summation:6813721] NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes chole...
(hasEvent)	[Pathway:8964038] LDL clearance [Homo sapiens]
(precedingEvent)	[Reaction:216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782957] Update Tracker - [Reaction:6813720] NCEH1 hydrolyzes cholesterol esters - v58:[add_removeInput, add_removeOutput, modifyText]
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