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Details on Person PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

Class:Id	Reaction:6811522
_displayName	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus
_doRelease	TRUE
_timestamp	2016-12-09 18:48:46
authored	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
catalystActivity	[CatalystActivity:6811451] 1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
edited	[InstanceEdit:8877766] Orlic-Milacic, Marija, 2016-06-27 [InstanceEdit:8942048] Orlic-Milacic, Marija, 2016-10-07
input	[SimpleEntity:6810408] PI5P [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6810416] Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta [LiteratureReference:6811521] Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7 [LiteratureReference:6811524] PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha
modified	[InstanceEdit:8877672] Orlic-Milacic, Marija, 2016-06-27 [InstanceEdit:8877768] Orlic-Milacic, Marija, 2016-06-27 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933581] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:8942050] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8948114] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8951734] Matthews, Lisa, 2016-12-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:6810412] PI(4,5)P2 [nucleoplasm]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933578] Divecha, Nullin, 2016-06-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8909432] R-HSA-6811522.3
summation	[Summation:6811525] In the nucleus, phosphatidylinositol 5-phosphate (PI5P) is p...
(hasEvent)	[Pathway:6811554] Regulation of PI5P Levels [Homo sapiens] [Pathway:6811555] PI5P Regulates TP53 Acetylation [Homo sapiens] [Pathway:8847453] Synthesis of PIPs in the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (6811522)