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Details on Person ING2-bound EP300 acetylates TP53

Class:Id	Reaction:6811508
_displayName	ING2-bound EP300 acetylates TP53
_doRelease	TRUE
_timestamp	2016-08-08 13:53:33
authored	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
catalystActivity	[CatalystActivity:6811481] protein-lysine-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
edited	[InstanceEdit:8877766] Orlic-Milacic, Marija, 2016-06-27
input	[Complex:3215194] ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3215218] ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation [LiteratureReference:6810384] The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor [LiteratureReference:6810400] Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933581] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ING2-bound EP300 acetylates TP53
output	[SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [Complex:6811488] ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6811479] ING2 recruits EP300 to TP53 [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveRegulation:8877675] Positive regulation by 'PI5P [nucleoplasm]'
regulationReference	[RegulationReference:9642999] Positive regulation by 'PI5P [nucleoplasm]' Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933578] Divecha, Nullin, 2016-06-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908516] R-HSA-6811508.4
summation	[Summation:6811510] The histone acetyltransferase EP300 (p300), recruited to TP5...
(hasEvent)	[Pathway:6811555] PI5P Regulates TP53 Acetylation [Homo sapiens]
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No pathways have been reviewed or authored by ING2-bound EP300 acetylates TP53 (6811508)