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Details on Person AKT1 dephosphorylation by PP2A-B56-beta,gamma

Class:Id	Reaction:6811504
_displayName	AKT1 dephosphorylation by PP2A-B56-beta,gamma
_doRelease	TRUE
_timestamp	2017-07-28 15:19:35
authored	[InstanceEdit:8850549] Orlic-Milacic, Marija, 2015-12-21
catalystActivity	[CatalystActivity:6811478] protein serine/threonine phosphatase activity of PP2A-B56-beta,gamma [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
edited	[InstanceEdit:8850549] Orlic-Milacic, Marija, 2015-12-21
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6811494] Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity [LiteratureReference:6811518] PtdIns5P protects Akt from dephosphorylation through PP2A inhibition [LiteratureReference:6811482] Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
modified	[InstanceEdit:8856766] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:8857927] Orlic-Milacic, Marija, 2016-02-17 [InstanceEdit:8944183] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:9014478] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 dephosphorylation by PP2A-B56-beta,gamma
output	[EntityWithAccessionedSequence:58252] AKT1 [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
regulatedBy	[NegativeRegulation:6811496] Negative regulation by 'PI5P [plasma membrane]'
regulationReference	[RegulationReference:9642252] Negative regulation by 'PI5P [plasma membrane]' PtdIns5P protects Akt from dephosphorylation through PP2A inhibition
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856765] Porteu, Fran�oise, 2016-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861021] R-HSA-6811504.6
summation	[Summation:6811487] The protein phosphatase 2A (PP2A) complex containing a regul...
(hasEvent)	[Pathway:6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Homo sapiens]
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